Aerobic exercise training induces a unique cardioprotective phenotype, but it is becoming clear that it does not promote the same structural, functional, and molecular adaptations in both ventricles. In the present study, we aimed to better characterize and compare the molecular pathways involved in the exercise-induced remodeling of both ventricles. Female Sprague-Dawley rats were randomly assigned to control and exercise groups. Animals in the exercise group were submitted to low-intensity treadmill exercise for 54 weeks. After the experimental period, biventricular hemodynamic analysis was performed and right and left ventricles were harvested for morphological and biochemical analyses. Data showed that long-term low-intensity exercise training improves cardiac function, especially left ventricular diastolic function; however, the expression of connexin-43, CCAAT-enhancer binding protein β, and c-kit did not change in none of the ventricles. In the right ventricle, long-term exercise training induced an increase of manganese superoxide dismutase and sirtuin 3 protein expression, suggestive of improved antioxidant capacity. Our results also support that long-term aerobic exercise training imposes greater metabolic remodeling to the right ventricle, mainly by increasing mitochondrial ability to produce ATP, with no association to estrogen-related receptor α regulation.

中文翻译：

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一年的运动训练可促进雌性Sprague-Dawley大鼠左右心室的明显适应。

有氧运动训练可诱导出独特的心脏保护表型，但越来越明显的是，它不能促进两个心室的结构，功能和分子适应性相同。在本研究中，我们旨在更好地表征和比较参与运动诱发的两个心室重塑的分子途径。将雌性Sprague-Dawley大鼠随机分为对照组和运动组。运动组的动物接受低强度跑步机运动54周。实验期过后，进行双心室血流动力学分析，并收集左右脑室进行形态学和生化分析。数据显示，长期低强度运动训练可改善心脏功能，尤其是左心室舒张功能。然而，连接蛋白43，CCAAT-增强子结合蛋白β和c-kit的表达在所有心室中均未改变。在右心室，长期的运动训练可导致锰超氧化物歧化酶和sirtuin 3蛋白表达增加，提示抗氧化能力增强。我们的研究结果还支持，长期的有氧运动训练主要是通过增加线粒体产生ATP的能力，而不是与雌激素相关的受体α调节相关，对右心室进行更大的代谢重塑。