Dipeptidyl peptidase‐4 inhibitor (DPP‐4 inhibitor) such as sitagliptin has been presented as antidiabetic drugs and has numerous restorative advantages over different diseases; however, its defensive role against aflatoxin b1 (AFB1) liver toxicity has not been previously examined. Wistar rats (65 weeks, male) were utilized in the investigation. Animals were divided into five different groups (n = 10): control; AFB1; AFB1 + Sita (50); AFB1 + Sita (100); and Sita (100). Sitagliptin significantly (*p ≤ .05, **p ≤ .01, and ***p ≤ .001) altered the levels of various serum liver enzymes (lactate dehydrogenase, alkaline phosphate, aspartate aminotransferase, and alanine aminotransferase). It decreased the concentration of an oxidative stress marker, that is, malondialdehyde and increased the level of antioxidant enzymes such as reduced glutathione, catalase, superoxide dismutase, and glutathione peroxidase in AFB1‐administered rats. It also improved the Nrf2 expression and HO‐1 level in AFB1‐intoxicated rats. This investigation discusses innovative evidence on the protective role of sitagliptin against AFB1‐induced hepatotoxicity in rats.

中文翻译：

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西他列汀通过上调Nrf2 / ARE / HO-1途径保护肝脏免受黄曲霉毒素B1诱导的肝毒性。

西他列汀等二肽基肽酶-4抑制剂（DPP-4抑制剂）已被认为是抗糖尿病药物，与不同疾病相比具有许多修复优势。但是，其抗黄曲霉毒素b1（AFB1）肝毒性的防御作用先前尚未得到检验。Wistar大鼠（65周，雄性）用于研究。将动物分为五个不同的组（n = 10）：对照组；对照组。AFB1；AFB1 +西塔（50）; AFB1 +西塔（100）; 和西塔（100）。西他列汀显著（* p  ≤.05，** p  ≤.01，和*** p ≤.001）改变了各种血清肝酶（乳酸脱氢酶，碱性磷酸酶，天冬氨酸转氨酶和丙氨酸转氨酶）的水平。它降低了AFB1给药大鼠中氧化应激标志物即丙二醛的浓度，并增加了抗氧化酶的水平，例如还原型谷胱甘肽，过氧化氢酶，超氧化物歧化酶和谷胱甘肽过氧化物酶。它还改善了AFB1中毒大鼠的Nrf2表达和HO-1水平。这项研究讨论了西他列汀对AFB1诱导的大鼠肝毒性的保护作用的创新证据。