Metals from the natural environment have potential hypertension effects. However, relevant studies on this topic are few. A total of 1358 adults aged 18-74 years from Chizhou, Maanshan, and Tongling of Anhui Province participated in the baseline study from 2014 to 2015. The follow-up study was performed from 2016 to 2017. Inductively coupled plasma optical emission spectrometry (7000 DV) was used to measure urinary Cr, Mn, Fe, Cu, and Zn of residents. Urinary concentrations of Cd determined via TAS-900 atomic absorption spectrophotometry at 228.8 nm wavelength. A total of 275 hypertension cases were identified. After adjusting for sociodemographic factors and risk factors for hypertension, four metals (Cd, Cr, Cu, and Mn) were significantly associated with hypertension in the single-metal model. Upon including all metals in the same model, the hazard ratios of the highest quartiles Cd and Cu compared with the reference group were 1.42 (95% confidence interval [CI] 1.09-2.02) and 1.56 (95% CI 1.16-2.09) for cases of hypertension. Our findings suggested that high levels of Cd and Cu might increase the incidence of hypertension. Further studies involving larger population should be conducted to confirm these findings.

中文翻译：

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长江沿岸成年居民尿液中的金属含量和高血压发病率

来自自然环境的金属具有潜在的高血压效应。但是，有关该主题的研究很少。2014年至2015年，来自安徽池州，马鞍山和铜陵的1358名年龄在18-74岁的成年人参加了基线研究。随访研究于2016年至2017年进行。电感耦合等离子体发射光谱法（7000 DV）用于测量居民的尿中Cr，Mn，Fe，Cu和Zn。通过TAS-900原子吸收分光光度法在228.8 nm波长处测定的尿中Cd浓度。总共确定了275例高血压病例。在调整了社会人口统计学因素和高血压的危险因素后，在单金属模型中，四种金属（Cd，Cr，Cu和Mn）与高血压显着相关。在将所有金属包括在同一模型中之后，与高血压组相比，最高四分位数Cd和Cu的危险比为1.42（95％置信区间[CI] 1.09-2.02）和1.56（95％CI 1.16-2.09）。我们的研究结果表明，高水平的镉和铜可能会增加高血压的发病率。应当进行涉及更多人口的进一步研究，以证实这些发现。