BACKGROUND Photothermal therapy is a local treatment method for cancer and the heat energy generated from it could destroy the tumor cells. This study is aimed to investigate the temperature distribution in tumor tissue and surrounding health tissue of tumor bearing mice applying mathematical simulation model. Tumor bearing mice treated by laser combined with or without indocyanine green. Monte Carlo method and the Pennes bio-heat equation were used to calculate the light distribution and heat energy. COMSOL Multiphysic was adopted to construct three dimensional temperature distribution model. RESULTS This study revealed that the data calculated by simulation model is in good agreement with the surface temperature monitored by infrared thermometer. Effected by the optical parameters and boundary conditions of tissue, the highest temperature of tissue treated by laser combined with indocyanine green was about 65 °C which located in tumor tissue and the highest temperature of tissue treated by laser was about 43 °C which located under the tumor tissue. The temperature difference was about 20 °C. Temperature distribution in tissue was not uniform. The temperature difference in different parts of tumor tissue raised up to 15 °C. The temperature of tumor tissue treated by laser combined with indocyanine green was about 20 °C higher than that of the surrounding healthy tissue. CONCLUSIONS Reasonably good matching between the calculated temperature and the measured temperature was achieved, thus demonstrated great utility of our modeling method and approaches for deepening understand in the temperature distribution in tumor tissue and surrounding healthy tissue during the laser combined with photosensitizer. The simulation model could provide guidance and reference function for the effect of photothermal therapy.

中文翻译：

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激光结合吲哚菁绿处理的肿瘤组织和周围健康组织中温度分布的数学模拟。

背景技术光热疗法是治疗癌症的局部方法，其产生的热能可能破坏肿瘤细胞。本研究旨在利用数学模拟模型研究荷瘤小鼠肿瘤组织和周围健康组织中的温度分布。激光治疗的荷瘤小鼠，结合或不结合吲哚菁绿。使用蒙特卡洛方法和潘尼斯生物热方程式计算光分布和热能。采用COMSOL Multiphysic建立三维温度分布模型。结果本研究表明，仿真模型计算得到的数据与红外测温仪监测的表面温度吻合良好。受光学参数和组织边界条件的影响，激光结合吲哚菁绿处理的组织的最高温度为约65℃，其位于肿瘤组织中，而激光处理的组织的最高温度为约43℃，其位于肿瘤组织下方。温差约为20℃。组织中的温度分布不均匀。肿瘤组织不同部位的温度差升高到15°C。激光结合吲哚菁绿处理的肿瘤组织的温度比周围健康组织的温度高约20°C。结论在计算温度和测量温度之间取得了合理的良好匹配，因此证明了我们的建模方法和方法在加深结合光敏剂的激光过程中加深对肿瘤组织和周围健康组织中温度分布了解的实用性。该仿真模型可为光热疗法的疗效提供指导和参考功能。