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What we say and what we mean when we say redundancy and robustness of the chemokine system - how CCR5 challenges these concepts.
Immunology and Cell Biology ( IF 4 ) Pub Date : 2019-10-15 , DOI: 10.1111/imcb.12291
Joel H Ellwanger 1 , Valéria de L Kaminski 1 , José Ab Chies 1
Affiliation  

Classically, robustness and redundancy are features that define the intricate and connected functioning of the chemokine system. Following these ideas, the lack of a particular chemokine or chemokine receptor could be compensated by the presence of other molecules with similar functions, ensuring robustness to the systems. Although these concepts are generally accepted, they represent an oversimplification of a highly complex system that works in a context-dependent manner. Based on different studies, and taking as an example the chemokine receptor CCR5 (C-C chemokine receptor type 5) and the genetic variant CCR5Δ32, which on several occasions challenge the classical concepts of redundancy and robustness of the chemokine system, we will discuss and question this general and oversimplified point of view.

中文翻译:

当我们说趋化因子系统的冗余性和鲁棒性时,我们所说的是什么-CCR5如何挑战这些概念。

传统上,鲁棒性和冗余是定义趋化因子系统复杂和相互联系的功能的特征。遵循这些想法,可以通过存在具有类似功能的其他分子来补偿特定趋化因子或趋化因子受体的缺乏,从而确保系统的坚固性。尽管这些概念已被普遍接受,但它们代表了以上下文相关方式工作的高度复杂的系统的过度简化。基于不同的研究,并以趋化因子受体CCR5(CC趋化因子受体5型)和遗传变异体CCR5Δ32为例,它们在很多情况下都对趋化因子系统的冗余性和鲁棒性的经典概念提出了挑战,我们将对此进行讨论和质疑。一般和过于简化的观点。
更新日期:2019-11-01
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