BACKGROUND Atopic dermatitis (AD) is the most common chronic skin disease in childhood. There is no definitive test for diagnosing AD. The Hanifin-Rajka criteria (HRC) and The United Kingdom Working Party criteria (UKC) are the most used in the literature. It is aimed to evaluate the clinical efficacy of HRC and UKC in pediatric age. METHODS Children diagnosed AD in the pediatric allergy clinic were enrolled. Patients with skin problems other than AD were involved as controls. All participants were evaluated for HRC and UKC at the time of diagnosis. Clinical diagnosis by the pediatric allergist was determined as the gold standard. RESULTS 200 children with AD and 90 controls were enrolled in the study. Median (interquartile range, IQR) age of AD patients was 13.5 (7-36) months. There was no significant difference in age and sex between groups (p=0.11 and p=0.34, respectively). The HRC were superior to the UKC for sensitivity, negative predictive value, kappa and accuracy rate (94% vs. 72%, 84% vs. 60%, 0.68 vs. 0.56 and 87 vs. 78, respectively). On the other hand, specificity and positive predictive value of UKC were better than those of HRC (92% vs. 71% and 95% vs. 88%, respectively). CONCLUSION HRC seem to be better in diagnosing AD than UKC for young children. Further studies are needed to evaluate comparableness of HRC and UKC for AD in childhood in order to generate an international consensus for clinical trials.

中文翻译：

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儿童特应性皮炎的诊断：Hanifin-Rajka与英国工作组标准的比较。

背景技术特应性皮炎（AD）是儿童时期最常见的慢性皮肤病。没有用于诊断AD的明确测试。Hanifin-Rajka标准（HRC）和英国工作组标准（UKC）在文献中使用最多。目的是评估HRC和UKC在小儿年龄段的临床疗效。方法纳入在小儿过敏诊所诊断为AD的儿童。患有AD以外的皮肤问题的患者作为对照。诊断时对所有参与者进行了HRC和UKC评估。小儿过敏症的临床诊断被确定为金标准。结果本研究纳入了200名AD儿童和90名对照。AD患者的中位（四分位间距，IQR）年龄为13.5（7-36）个月。两组之间的年龄和性别无显着差异（分别为p = 0.11和p = 0.34）。在敏感性，阴性预测值，kappa和准确率方面，HRC优于UKC（分别为94％对72％，84％对60％，0.68对0.56和87对78）。另一方面，UKC的特异性和阳性预测值优于HRC（分别为92％对71％和95％对88％）。结论对于幼儿，HRC似乎比UKC更能诊断AD。为了在临床试验中达成国际共识，需要进一步的研究来评估HRC和UKC在儿童期AD的可比性。另一方面，UKC的特异性和阳性预测值优于HRC（分别为92％对71％和95％对88％）。结论对于幼儿，HRC似乎比UKC更能诊断AD。为了在临床试验中达成国际共识，需要进一步的研究来评估HRC和UKC在儿童期AD的可比性。另一方面，UKC的特异性和阳性预测值优于HRC（分别为92％对71％和95％对88％）。结论对于幼儿，HRC似乎比UKC更能诊断AD。为了在临床试验中达成国际共识，需要进一步的研究来评估HRC和UKC在儿童期AD的可比性。