Regenerative processes that maintain the function of the gastrointestinal (GI) epithelium are critical for health and survival of multicellular organisms. In insects and vertebrates, intestinal stem cells (ISCs) regenerate the GI epithelium. ISC function is regulated by intrinsic, local, and systemic stimuli to adjust regeneration to tissue demands. These control mechanisms decline with age, resulting in significant perturbation of intestinal homeostasis. Processes that lead to this decline have been explored intensively in Drosophila melanogaster in recent years and are now starting to be characterized in mammalian models. This review presents a model for age-related regenerative decline in the fly intestine and discusses recent findings that start to establish molecular mechanisms of age-related decline of mammalian ISC function.

中文翻译：

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肠干细胞老化：起源和干预。

维持胃肠道（GI）上皮功能的再生过程对于多细胞生物的健康和生存至关重要。在昆虫和脊椎动物中，肠干细胞（ISC）可以再生GI上皮。ISC功能受内在的，局部的和全身的刺激调节，以根据组织需求调节再生。这些控制机制随着年龄的增长而下降，从而导致肠道稳态的明显扰动。近年来，在果蝇中已经深入研究了导致这种下降的过程，现在已经开始在哺乳动物模型中对其进行表征。这篇综述提出了苍蝇肠道中与年龄相关的再生下降的模型，并讨论了最近的发现，这些发现开始建立哺乳动物ISC功能与年龄相关的下降的分子机制。