Abstract Objective: The use of psychoactive substances has been one of the most important global public health problems over the last few decades. Among the problems associated with substance use, dual diagnosis is one of the most relevant. This study aims to investigate the predictive validity of the GHQ-28 (General Health Questionnaire-28; “probable psychiatric cases”) in relation to poor treatment outcome measured by (a) “early treatment dropout” and (b) “nonclinically relevant improvement at discharge.” Methods: A longitudinal prospective design was used. A sample of 219 substance use disorder patients, who received treatment in a therapeutic community, was selected. Patients were assessed using the GHQ-28 and the outcome variables were registered. A hierarchical logistic regression model was performed to identify factors independently associated with the outcome measure (“early treatment dropout” and “nonclinically relevant improvement at discharge”). Results: Of the total sample, 79 subjects (36%) were considered “early treatment dropouts” and 56.6% (102) presented a “nonclinically relevant improvement at discharge.” The two hierarchical logistic regression results show that being classified as a “probable psychiatric case” was significantly and directly associated with “early treatment dropout” and “nonclinically relevant improvement at discharge,” as a poor in-treatment outcome indicator. Conclusions: The results of this study support the notion that the probable psychiatric cases identified by the GHQ-28 scale have a greater probability of “early treatment dropout” and have a greater probability of “nonclinically relevant improvement in discharge” of the therapeutic community. These data indicate that GHQ-28 is a suitable clinical instrument for predicting dropout and treatment effect in residential substance use disorder treatment.

中文翻译：

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一般健康问卷 (GHQ-28) 对在治疗社区接受治疗的药物滥用患者的预测结果有效性

摘要 目的：在过去的几十年中，精神活性物质的使用已成为最重要的全球公共卫生问题之一。在与物质使用相关的问题中，双重诊断是最相关的问题之一。本研究旨在调查 GHQ-28（一般健康问卷 28；“可能的精神病病例”）与通过（a）“早期治疗退出”和（b）“非临床相关改善”衡量的不良治疗结果相关的预测有效性出院时。” 方法：采用纵向前瞻性设计。选择了在治疗社区接受治疗的 219 名物质使用障碍患者的样本。使用 GHQ-28 评估患者并记录结果变量。执行分层逻辑回归模型以识别与结果测量独立相关的因素（“早期治疗退出”和“出院时非临床相关的改善”）。结果：在总样本中，79 名受试者 (36%) 被认为是“早期治疗辍学”，56.6% (102) 名受试者表现出“出院时非临床相关的改善”。两个分层逻辑回归结果表明，被归类为“可能的精神病病例”与“早期治疗退出”和“出院时非临床相关改善”显着且直接相关，这是一个较差的治疗结果指标。结论：这项研究的结果支持这样一种观点，即 GHQ-28 量表确定的可能的精神病病例“早期治疗退出”的可能性更大，治疗界“非临床相关的出院改善”的可能性更大。这些数据表明，GHQ-28 是一种合适的临床工具，可用于预测住宅物质使用障碍治疗中的辍学和治疗效果。