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Determination of oxygen r1 at 3 Tesla using samples with a concentration range of dissolved oxygen.
Magnetic Resonance Materials in Physics Biology and Medicine ( IF 2.3 ) Pub Date : 2019-10-12 , DOI: 10.1007/s10334-019-00783-x
Svein Are Sirirud Vatnehol 1, 2, 3 , Per Kristian Hol 1, 2 , Atle Bjørnerud 4, 5 , Mahmood Amiry-Moghaddam 1, 3 , Camilla Haglerød 3 , Tryggve Holck Storås 6
Affiliation  

OBJECTIVE To investigate the sensitivity of modified Look-Locker inversion recovery (MOLLI) to measure changes in dissolved oxygen (DO) concentrations in water samples and to calculate sequence-specific relaxivity (r1m) and limit of detection (LOD). MATERIALS AND METHODS Ten water samples with a range of DO concentrations were scanned at 3 T using two variations of MOLLI schemes. Using linear regression the r1 of DO was estimated from the measured DO concentrations and T1 relaxation rates (R1). The results were combined with previously reported values on in vivo stability measures of the MOLLI sequences and used to estimate a LOD. RESULTS DO concentrations ranged from 0.5 to 21.6 mg L-1. A linear correlation between DO and R1 was obtained with both MOLLI sequences, with an average correlation coefficient (R2) 0.9 and an average estimated r1 ([Formula: see text]) of 4.45 × 10-3 s-1 mg-1 L. Estimated LOD was ≈ 10 mg L-1. CONCLUSION MOLLI T1-mapping sequences may be used for detecting dissolved oxygen in vivo at 3 T with an [Formula: see text] in the range 4.18-4.8 × 10-3 s-1 mg-1 L and a corresponding LOD for dissolved oxygen of approximately 10 mg L-1. MOLLI-based T1 mapping may be a useful non-invasive tool for quantification of in vivo changes of DO concentration during oxygen challenges.

中文翻译:

使用溶解氧浓度范围的样品在3 Tesla下测定氧气r1。

目的研究改良的Look-Locker反转恢复(MOLLI)的灵敏度,以测量水样中溶解氧(DO)的浓度,并计算序列特异性弛豫度(r1m)和检测极限(LOD)。材料和方法使用两种MOLLI方案,在3 T下扫描了十种具有一定DO浓度的水样品。使用线性回归,根据测得的DO浓度和T1弛豫率(R1)估算DO的r1。将结果与先前报道的有关MOLLI序列的体内稳定性测量值结合起来,并用于估计LOD。结果DO浓度范围为0.5至21.6 mg L-1。使用两个MOLLI序列获得DO和R1之间的线性相关性,平均相关系数(R2)为0。9和平均估计r1([公式:参见文本])为4.45×10-3 s-1 mg-1L。估计的LOD为≈10 mg L-1。结论MOLLI T1映射序列可用于检测3 T时的体内溶解氧,其[公式:参见文本]范围为4.18-4.8×10-3 s-1 mg-1 L,并具有相应的溶解氧LOD约10毫克L-1。基于MOLLI的T1映射可能是一种有用的非侵入性工具,用于量化氧激发期间体内DO浓度的变化。
更新日期:2019-10-12
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