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Advanced MR imaging of bone marrow: quantification of signal alterations on T1-weighted Dixon and T2-weighted Dixon sequences in red marrow, yellow marrow, and pathologic marrow lesions.
Skeletal Radiology ( IF 2.1 ) Pub Date : 2019-10-12 , DOI: 10.1007/s00256-019-03303-z Chayanit Sasiponganan 1 , Kevin Yan 1 , Parham Pezeshk 1 , Yin Xi 1 , Avneesh Chhabra 1, 2
Skeletal Radiology ( IF 2.1 ) Pub Date : 2019-10-12 , DOI: 10.1007/s00256-019-03303-z Chayanit Sasiponganan 1 , Kevin Yan 1 , Parham Pezeshk 1 , Yin Xi 1 , Avneesh Chhabra 1, 2
Affiliation
OBJECTIVES
To quantify and compare signal intensity (SI) changes on T1-weighted (W) and T2W Dixon imaging in yellow marrow, red marrow, and bone marrow lesions.
MATERIALS AND METHODS
A total of 141 patients (77 controls, 64 lesions-33 benign, 31 malignant) between January 2016 and December 2017 were retrospectively identified. For the control group, fixed 2-cm2 region of interests (ROI) were drawn at L5, bilateral ilium and femurs on in-phase and opposed-phase T1W and T2W Dixon images. For the lesion group, ROIs of best fit were drawn around each lesion on in-phase and opposed-phase T2W Dixon images. SI changes between in-phase and opposed phase maps for each group were compared. Inter-reader analysis was performed.
RESULTS
Yellow marrow exhibited smaller SI changes as compared to red marrow on both T1W and T2W Dixon imaging at all locations (p < 0.0001) except at L5 on T2W Dixon imaging (p = 0.206). Both benign and malignant lesions showed significantly smaller SI changes as compared to both yellow (p = 0.0087, p < 0.0001) and red marrow (p = 0.0004, p < 0.0001) on T2W Dixon imaging. Malignant lesions exhibited smaller SI change as compared to benign lesions on T2W Dixon imaging (p = 0.0005). Signal intensity loss on both red and yellow marrow were smaller on T1W Dixon as compared to T2W Dixon (0.49-0.64, 0.27-0.31 vs. 0.70-0.74, 0.48-0.71). Inter-reader agreements were excellent (0.91-0.97).
CONCLUSIONS
SI change calculated from T2-weighted Dixon imaging can adequately differentiate between yellow marrow, red marrow, and osseous lesions, both benign and malignant.
中文翻译:
骨髓的高级MR成像:量化红,黄骨髓和病理性骨髓病变中T1加权Dixon和T2加权Dixon序列的信号改变。
目的要量化和比较黄,红,骨髓和骨髓病变的T1加权(W)和T2W Dixon成像的信号强度(SI)变化。材料与方法回顾性分析了2016年1月至2017年12月间的141例患者(77例对照,64例病变-33例良性,31例恶性)。对于对照组,在同相和反相T1W和T2W Dixon图像上的L5,双侧i骨和股骨处绘制了固定的2-cm2感兴趣区域(ROI)。对于病变组,在同相和反相T2W Dixon图像上的每个病变周围绘制最佳拟合的ROI。比较了各组的同相图和相反相图之间的SI变化。阅读器间分析。结果在T1W和T2W Dixon成像的所有位置(p <0.0001),除了在T2W Dixon成像的L5处(p = 0.206),黄骨髓的SI变化均比红骨髓小。在T2W Dixon成像中,与黄色(p = 0.0087,p <0.0001)和红色骨髓(p = 0.0004,p <0.0001)相比,良性和恶性病变均显示出明显较小的SI变化。与T2W Dixon成像上的良性病变相比,恶性病变表现出较小的SI变化(p = 0.0005)。与T2W Dixon相比,T1W Dixon在红色和黄色骨髓上的信号强度损失都较小(0.49-0.64,0.27-0.31,而0.70-0.74,0.48-0.71)。阅读器之间的协议非常好(0.91-0.97)。结论根据T2加权Dixon成像计算得出的SI改变可充分区分黄骨髓,红骨髓和骨性病变,
更新日期:2020-02-14
中文翻译:
骨髓的高级MR成像:量化红,黄骨髓和病理性骨髓病变中T1加权Dixon和T2加权Dixon序列的信号改变。
目的要量化和比较黄,红,骨髓和骨髓病变的T1加权(W)和T2W Dixon成像的信号强度(SI)变化。材料与方法回顾性分析了2016年1月至2017年12月间的141例患者(77例对照,64例病变-33例良性,31例恶性)。对于对照组,在同相和反相T1W和T2W Dixon图像上的L5,双侧i骨和股骨处绘制了固定的2-cm2感兴趣区域(ROI)。对于病变组,在同相和反相T2W Dixon图像上的每个病变周围绘制最佳拟合的ROI。比较了各组的同相图和相反相图之间的SI变化。阅读器间分析。结果在T1W和T2W Dixon成像的所有位置(p <0.0001),除了在T2W Dixon成像的L5处(p = 0.206),黄骨髓的SI变化均比红骨髓小。在T2W Dixon成像中,与黄色(p = 0.0087,p <0.0001)和红色骨髓(p = 0.0004,p <0.0001)相比,良性和恶性病变均显示出明显较小的SI变化。与T2W Dixon成像上的良性病变相比,恶性病变表现出较小的SI变化(p = 0.0005)。与T2W Dixon相比,T1W Dixon在红色和黄色骨髓上的信号强度损失都较小(0.49-0.64,0.27-0.31,而0.70-0.74,0.48-0.71)。阅读器之间的协议非常好(0.91-0.97)。结论根据T2加权Dixon成像计算得出的SI改变可充分区分黄骨髓,红骨髓和骨性病变,