Converging lines of evidence point to a significant role of neuroinflammation in a host of psychiatric conditions, including alcohol use disorder, TBI, and PTSD. A complex interaction of both peripheral and central signaling underlies processes involved in neuroinflammation. Calcineurin is a molecule that sits at the nexus of these processes and has been clearly linked to a number of psychiatric disorders including alcohol use disorder (AUD). Like its role in regulating peripheral immune cells, calcineurin (CN) plays an integral role in processes regulating neuroimmune function and neuroinflammatory processes. Targeting CN or elements of its signaling pathways at critical points may aid in the functional recovery from neuroinflammatory related disorders. In this review we will highlight the role of neuroinflammation and calcineurin signaling in AUD, TBI and stress-induced disorders and discuss recent findings demonstrating a therapeutic effect of immunosuppressant-induced calcineurin inhibition in a pre-clinical model of binge alcohol drinking.

越来越多的证据表明，神经炎症在许多精神疾病（包括饮酒障碍，TBI和PTSD）中起着重要作用。周围和中央信号传导的复杂相互作用是神经发炎过程的基础。钙调神经磷酸酶是位于这些过程之间的一个分子，并且已与包括酒精滥用症（AUD）在内的许多精神疾病明确相关。就像其在调节外周免疫细胞中的作用一样，钙调神经磷酸酶（CN）在调节神经免疫功能和神经炎症过程中起着不可或缺的作用。将CN或其信号传导途径的元件靶向于关键点可以帮助从神经炎性相关疾病中恢复功能。