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Lycopene solid lipid microparticles with enhanced effect on gingival crevicular fluid protein carbonyl as a biomarker of oxidative stress in patients with chronic periodontitis
Journal of Liposome Research ( IF 4.4 ) Pub Date : 2019-02-22 , DOI: 10.1080/08982104.2019.1566243
Maie S Tawfik 1 , Khaled A Abdel-Ghaffar 1 , Ahmed Y Gamal 1 , Fatma H El-Demerdash 1 , Heba A Gad 2
Affiliation  

Abstract Lycopene (LP), a naturally occurring carotenoid in red-coloured fruits, especially tomatoes, has a pivotal role in counteracting the deleterious effect of oxidative stress on periodontal tissues. The aim of this study is to prepare solid lipid microparticles (SLMs) encapsulating LP and to assess their biochemical and clinical effects in the management of chronic periodontitis. Optimization of SLMs was performed by assessing particle size and LP entrapment efficiency. Clinical study included 16 chronic periodontitis patients allocated into two groups, Group I was managed by scaling and root planing (SRP) and local delivery of LP loaded SLMs, while Group II was managed by SRP only. Protein carbonyl (PC) levels as a biomarker of oxidative stress and drug concentration in gingival crevicular fluid (GCF) were assessed at different time intervals. Results revealed that optimum formula of SLMs had a particle size of 77.28 µm and entrapped 98.03% of LP. SLMs recorded 30 d of drug release with no burst effect. Patients treated with LP SLMs showed significantly lower levels of PC after SRP compared to those treated with SRP only, in addition to improvement in the measured clinical parameters. In conclusion, locally delivered LP SLMs along with SRP could have a protective effect over periodontal tissues and it has the ability to decrease oxidative damage of proteins in diseased periodontium.

中文翻译:

番茄红素固体脂质微粒对作为慢性牙周炎患者氧化应激生物标志物的龈沟液羰基蛋白具有增强作用

摘要 番茄红素 (LP) 是一种天然存在于红色水果,尤其是西红柿中的类胡萝卜素,在抵消氧化应激对牙周组织的有害影响方面具有关键作用。本研究的目的是制备包裹 LP 的固体脂质微粒 (SLM),并评估它们在慢性牙周炎治疗中的生化和临床效果。SLM 的优化是通过评估颗粒大小和 LP 截留效率来进行的。临床研究包括 16 名慢性牙周炎患者,分为两组,第 I 组通过刮治和根面平整 (SRP) 和局部递送加载 LP 的 SLM 进行管理,而第 II 组仅由 SRP 管理。在不同时间间隔评估作为氧化应激生物标志物的蛋白质羰基 (PC) 水平和龈沟液 (GCF) 中的药物浓度。结果表明,SLM 的最佳配方具有 77.28 µm 的粒径和 98.03% 的 LP。SLM 记录了 30 天的药物释放,没有爆发效应。与仅接受 SRP 治疗的患者相比,接受 LP SLM 治疗的患者在 SRP 后的 PC 水平显着降低,此外还改善了测量的临床参数。总之,局部递送的 LP SLM 和 SRP 可以对牙周组织产生保护作用,并具有减少患病牙周组织中蛋白质氧化损伤的能力。SLM 记录了 30 天的药物释放,没有爆发效应。与仅接受 SRP 治疗的患者相比,接受 LP SLM 治疗的患者在 SRP 后的 PC 水平显着降低,此外还改善了测量的临床参数。总之,局部递送的 LP SLM 和 SRP 可以对牙周组织产生保护作用,并具有减少患病牙周组织中蛋白质氧化损伤的能力。SLM 记录了 30 天的药物释放,没有爆发效应。与仅接受 SRP 治疗的患者相比,接受 LP SLM 治疗的患者在 SRP 后的 PC 水平显着降低,此外还改善了测量的临床参数。总之,局部递送的 LP SLM 和 SRP 可以对牙周组织产生保护作用,并具有减少患病牙周组织中蛋白质氧化损伤的能力。
更新日期:2019-02-22
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