Background/Aims: National guidelines endorse using evidence-based tools to identify those at risk for hereditary breast and ovarian cancer (HBOC). This study aimed to evaluate whether women deemed not to be at increased risk of being a BRCA mutation carrier; the majority of those screened, recall, understand and accept the implications of these results for breast cancer risk. Methods: We conducted an online survey with women (n = 148) who screened negative on a brief HBOC screener. Results: While women tended to accept HBOC screener as accurate (range 9–45; mean 32, SD 5.0), less than half (43%) accurately recalled their result. Only 52% understood that they were at low risk of carrying a mutation, and just 34% correctly understood their breast cancer risk. African American women were less likely to recall (33 vs. 53% respectively, OR 0.5, p = 0.03), understand (42 vs. 63% respectively, OR 0.4, p = 0.02), and accept (mean 31 vs. 33 respectively, β –2.1, p = 0.02) the result compared to Whites. Conclusions: Our findings show that those at low risk of carrying a BRCA1/2 mutation had limited understanding of the distinction between mutation risk and breast cancer risk. Theory-based communication strategies are needed to increase the understanding of the implications of being at low risk for hereditary cancers.

中文翻译：

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接受阴性BRCA1/2风险结果的女性是否了解对乳腺癌风险的影响？

背景/目的：国家指南支持使用循证工具来识别那些有遗传性乳腺癌和卵巢癌 (HBOC) 风险的人。本研究旨在评估被认为不会增加 BRCA 突变携带者风险的女性；大多数筛查、回忆、理解并接受这些结果对乳腺癌风险的影响。方法：我们对女性（n = 148）进行了一项在线调查，她们在简短的 HBOC 筛查中筛查结果为阴性。结果：虽然女性倾向于接受 HBOC 筛查仪准确（范围 9-45；平均 32，SD 5.0），但只有不到一半 (43%) 能准确回忆起她们的结果。只有 52% 的人知道他们携带突变的风险很低，只有 34% 的人正确理解了他们患乳腺癌的风险。非裔美国女性不太可能回忆起（分别为 33% 和 53%，OR 0.5，p = 0。03)，理解（分别为 42% 对 63%，OR 0.4，p = 0.02），并接受（分别为 31 对 33，β –2.1，p = 0.02）与白人相比的结果。结论：我们的研究结果表明，携带 BRCA1/2 突变风险低的人对突变风险和乳腺癌风险之间的区别理解有限。需要基于理论的交流策略来增加对遗传性癌症低风险影响的理解。