We aimed to investigate the efficacy of preemptive analgesia of celecoxib on postoperative pain, patients’ global assessment (PGA) and hip function recovery compared to postoperative analgesia of celecoxib in femoroacetabular impingement (FAI) patients who underwent hip arthroscopy surgery (HAS). The 100 FAI patients underwent HAS were randomly allocated to preemptive analgesia group (N = 50) or postoperative analgesia group (N = 50) as a 1:1 ratio for 3 months. Pain visual analog scale (VAS) score, PGA score, rescue-use pethidine consumption and Harris hip score were assessed. Compared to postoperative analgesia group, pain VAS score decreased on day 1 (P = 0.036), day 2 (P = 0.046) and day 3 (P = 0.046), while was similar prior to operation (P = 0.587), on day 7 (P = 0.398), at month 1 (P = 0.461) and month 3 (P = 0.805) in preemptive analgesia group. Besides, rescue-use pethidine consumption was decreased in preemptive analgesia group than postoperative analgesia group within 3 days (P = 0.016) and within 7 days (P = 0.033) post-operation. For PGA score, it reduced on day 2 (P = 0.030) and day 3 (P = 0.048), while was similar prior to operation (P = 0.699), on day 1 (P = 0.699), day 7 (P = 0.224), at month 1 (P = 0.640) and month 3 (P = 0.400) in preemptive analgesia group than postoperative analgesia group. For Harris hip score, it was similar prior to operation (P = 0.372), on day 7 (P = 0.366), at month 1 (P = 0.466) and month 3 (P = 0.658) between the two groups. In conclusion, preemptive analgesia of celecoxib decreases short-term postoperative pain and PGA, but without effect on long-term hip function recovery than postoperative analgesia of celecoxib in FAI patients who underwent HAS.

中文翻译：

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先天性镇痛与塞来昔布术后镇痛对股骨髋臼撞击患者的术后疼痛，患者总体评估和髋关节功能恢复的疗效。

我们旨在研究塞来昔布先行镇痛对接受髋关节镜手术（HAS）的股骨髋臼撞击（FAI）患者的术后疼痛，患者总体评估（PGA）和髋关节功能恢复与塞来昔布术后镇痛的效果相比。100例接受HAS的FAI患者 以1：1的比例随机分配至先发性镇痛组（N  = 50）或术后镇痛组（N = 50），为期3个月。评估疼痛视觉模拟量表（VAS）评分，PGA评分，救援用哌替丁消耗量和Harris髋关节评分。与术后镇痛组相比，第1天（P  = 0.036），第2天（P  = 0.046）和第3天（P = 0.046），尽管类似，但术前 镇痛组 在第7天（P  = 0.398），第1月（P  = 0.461）和第3月（P = 0.805）相似（P = 0.587）。此外，抢先镇痛组的抢救用哌替丁的消耗量在术后3天（P  = 0.016）和术后7天（P  = 0.033）比术后镇痛组减少。对于PGA评分，在第2天（P  = 0.030）和第3天（P  = 0.048）降低，而在手术前（P  = 0.699），在第1天（P  = 0.699）和第7天（P  = 0.224 ）相似。），在第1个月（P 先发性镇痛组比术后镇痛组 = 0.640）和第3个月（P = 0.400）。对于Harris髋关节评分， 两组之间在手术前（P  = 0.372），第7天（P  = 0.366），第1个月（P  = 0.466）和第3个月（P = 0.658）相似。总之，与接受HAS的FAI患者相比，塞来昔布的先行镇痛可减少短期术后疼痛和PGA，但对长期髋关节功能恢复没有影响。