BACKGROUND Many novel biomaterials have been incorporated in toothpastes to promote remineralization of tooth structure. OBJECTIVES This study was carried out to compare the discrepancies between declared and actual total fluoride (TF) or total soluble fluoride (TSF) concentration of two modern toothpastes containing bioactive glasses; these were also assessed for their remineralization potential. MATERIALS AND METHODS The TF and TSF concentration were assessed using a fluoride ion selective electrode. Enamel remineralization was evaluated through micro-hardness analysis. Eighteen enamel blocks were divided into three groups: 1 (n = 6; control), 2 (n = 6; Novamin® toothpaste), and 3 (n = 6; BiominF® toothpaste). The specimens were demineralized by 6 wt% citric acid (pH = 2.2). Subsequently, the specimens in group 1 were kept in artificial saliva (AS), while the specimens in groups 2 and 3 were stored in AS + Novamin® and AS + Biomin®, respectively. RESULTS Both Novamin® or BiominF® showed less TF concentration than their label claims. BiominF® had more TF and TSF compared to Novamin® (p < 0.05). The BiominF® toothpaste presented higher micro-hardness values on remineralization. CONCLUSION BiominF® toothpaste demonstrated more fluoride content and greater potential to promote remineralization of demineralized human enamel compared to Novamin®.

中文翻译：

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两种含不同生物活性玻璃的牙膏的氟化物含量和牙釉质再矿化潜力的体外评估。

背景技术许多新型生物材料已被掺入牙膏中以促进牙齿结构的再矿化。目的进行本研究以比较两种含生物活性玻璃的现代牙膏的标称和实际总氟化物（TF）或总可溶性氟化物（TSF）浓度之间的差异。还评估了它们的再矿化潜力。材料与方法使用氟离子选择电极评估TF和TSF的浓度。牙釉质再矿化通过显微硬度分析进行评估。将十八个搪瓷块分为三组：1组（n = 6；对照组），2组（n = 6；Novamin®牙膏）和3组（n = 6；BiominF®牙膏）。用6 wt％的柠檬酸（pH = 2.2）对样品进行脱盐。后来，第1组的标本保存在人工唾液（AS）中，而第2组和第3组的标本分别保存在AS +Novamin®和AS +Biomin®中。结果Novamin®或BiominF®均显示出比其标签声称更低的TF浓度。与Novamin®相比，BiominF®具有更多的TF和TSF（p <0.05）。BiominF®牙膏在矿化后具有更高的显微硬度值。结论与Novamin®相比，BiominF®牙膏具有更高的氟化物含量和更大的潜力，可促进脱矿质人类牙釉质的再矿化。BiominF®牙膏在矿化后具有更高的显微硬度值。结论与Novamin®相比，BiominF®牙膏具有更高的氟化物含量和更大的潜力，可促进脱矿质人类牙釉质的再矿化。BiominF®牙膏在矿化后具有更高的显微硬度值。结论与Novamin®相比，BiominF®牙膏具有更高的氟化物含量和更大的潜力，可促进脱矿质人类牙釉质的再矿化。