During neuronal development, the formation of neural circuits requires developing axons to traverse a diverse cellular and molecular environment to establish synaptic contacts with the appropriate postsynaptic partners. Essential to this process is the ability of developing axons to navigate guidance molecules presented by specialized populations of cells. These cells partition the distance traveled by growing axons into shorter intervals by serving as intermediate targets, orchestrating the arrival and departure of axons by providing attractive and repulsive guidance cues. The floor plate in the central nervous system (CNS) is a critical intermediate target during neuronal development, required for the extension of commissural axons across the ventral midline. In this review, we begin by giving a historical overview of the ventral commissure and the evolutionary purpose of decussation. We then review the axon guidance studies that have revealed a diverse assortment of midline guidance cues, as well as genetic and molecular regulatory mechanisms required for coordinating the commissural axon response to these cues. Finally, we examine the contribution of dysfunctional axon guidance to neurological diseases.

中文翻译：

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发育中的脊髓的连合轴突引导：从Cajal到今天。

在神经元发育过程中，神经回路的形成需要发育轴突来穿越不同的细胞和分子环境，以与适当的突触后伴侣建立突触接触。该过程必不可少的是发育轴突的能力，以操纵由专门的细胞群呈现的指导分子。这些细胞通过充当中间目标，将通过生长轴突而传播的距离划分为更短的间隔，通过提供有吸引力的和排斥的引导线索来协调轴突的到达和离开。中枢神经系统（CNS）的底板是神经元发育过程中的关键中间目标，这是连合轴突延伸穿过腹中线所必需的。在这篇评论中 我们首先对腹侧连合及其讨论的进化目的进行历史概述。然后，我们回顾了轴突导向研究，该研究揭示了各种各样的中线导向线索，以及协调连合轴突对这些线索的响应所需的遗传和分子调控机制。最后，我们研究了轴突功能失调对神经系统疾病的贡献。