Objective Spontaneous activity in the abdominal ganglion of Aplysia can be used as a convenient bioelectricity source in tests of novel MRI-based functional imaging methods, such as functional Magnetic Resonance Electrical Impedance Tomography (fMREIT). In these tests, it is necessary to find a consistent treatment that modulates neural activity, so that these results can be compared with control data. Effects of MREIT imaging currents combined with treatment were also of interest. Approach Potassium chloride (KCl) was employed as a rhythm modulator. In a series of experiments, effects of adding different volumes of KCl solution were tested and compared with experiments on control groups that had artificial sea water administered. In all cases, neuronal activity was measured with micro electrode arrays. Main results It was possible to reversibly stop spontaneous activity in ganglia by increasing the extracellular potassium chloride concentration to 89 mM. There was no effect on experimental outcomes when current was administered to the sample chamber between recordings. Significance KCl can be used as a reversible neural modulator for testing neural detection methods.

中文翻译：

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氯化钾对海兔腹神经节活动的影响

目的 海兔腹部神经节的自发活动可作为一种方便的生物电源，用于测试基于 MRI 的新型功能成像方法，如功能磁共振电阻抗断层扫描 (fMREIT)。在这些测试中，有必要找到一种调节神经活动的一致治疗方法，以便将这些结果与对照数据进行比较。MREIT 成像电流与治疗相结合的效果也很有趣。方法 使用氯化钾 (KCl) 作为节律调节剂。在一系列实验中，测试了添加不同体积的 KCl 溶液的效果，并与给予人工海水的对照组的实验进行了比较。在所有情况下，神经元活动都是用微电极阵列测量的。主要结果 通过将细胞外氯化钾浓度增加到 89 mM，可以可逆地停止神经节中的自发活动。在记录之间向样品室施加电流时，对实验结果没有影响。意义 KCl 可用作测试神经检测方法的可逆神经调节剂。