The Asian plant Kalimeris shimadai has been used as food and ethnologic medicine for over a thousand years. In this study, we isolated and identified one new lignan, kalshiolin A (1), and 12 known lignans (2-13). The structures were characterized by the comprehensive analyses of spectroscopic data (HR-ESI-MS, IR, 1D, and 2D-NMR) and the absolute configuration of 1 was determined from ECD calculations. The new compound 1 was also screened for cytotoxic activity but did not show significant potency (IC50 35.9-43.3 μM) against A549, MDA-MB-231, MCF7, KB, and KB-VIN cell lines.

中文翻译：

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Kalshiris shimadai的新木脂素KalshiolinA。

亚洲植物Kalimeris shimadai被用作食品和人种医学已有一千多年的历史了。在这项研究中，我们分离并鉴定了一种新的木脂素，kalshiolin A（1）和12种已知的木脂素（2-13）。通过对光谱数据（HR-ESI-MS，IR，1D和2D-NMR）进行全面分析来表征结构，并通过ECD计算确定1的绝对构型。还筛选了新化合物1的细胞毒性活性，但未显示出对A549，MDA-MB-231，MCF7，KB和KB-VIN细胞系的显着效力（IC50 35.9-43.3μM）。