Rab GTPases are key regulators of vesicle-mediated transport and are proposed to play a crucial role in the pathobiology of Parkinson's disease. As membrane trafficking seems to be a relevant pathway altered in Parkinson' disease, understanding the role of Rab GTPases in the disease progression could open a window for therapeutic interventions. In this review, we focus on the recent advances on the role of Rab GTPases in the biology of two main proteins involved in Parkinson's disease: LRRK2 and α-synuclein, given that mutations in their genes (LRRK2 and SNCA) cause familial and sporadic Parkinson's disease.

中文翻译：

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Rab GTPases在帕金森氏病病理生物学中的作用。

Rab GTPases是小泡介导运输的关键调节剂，被认为在帕金森氏病的病理生物学中起着至关重要的作用。由于膜运输似乎是帕金森氏病改变的相关途径，因此了解Rab GTPases在疾病进展中的作用可能为治疗性干预打开一扇窗户。在这篇综述中，我们关注Rab GTPases在涉及帕金森氏病的两种主要蛋白质生物学中的作用的最新进展，因为它们的基因突变（LRRK2和SNCA）会导致家族性和散发性帕金森氏症疾病。