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Transition metals and host-microbe interactions in the inflamed intestine.
Biometals ( IF 3.5 ) Pub Date : 2019-02-20 , DOI: 10.1007/s10534-019-00182-8
Wenhan Zhu 1 , Luisella Spiga 1 , Sebastian Winter 1
Affiliation  

Host-associated microbial communities provide critical functions for their hosts. Transition metals are essential for both the mammalian host and the majority of commensal bacteria. As such, access to transition metals is an important component of host-microbe interactions in the gastrointestinal tract. In mammals, transition metal ions are often sequestered by metal binding proteins to limit microbial access under homeostatic conditions. In response to invading pathogens, the mammalian host further decreases availability of these micronutrients by regulating their trafficking or releasing high-affinity metal chelating proteins, a process termed nutritional immunity. Bacterial pathogens have evolved several mechanisms to subvert nutritional immunity. Here, we provide an overview on how metal ion availability shapes host-microbe interactions in the gut with a particular focus on intestinal inflammatory diseases.

中文翻译:

肠道中的过渡金属和宿主微生物相互作用。

宿主相关的微生物群落为其宿主提供关键功能。过渡金属对于哺乳动物宿主和大多数共生细菌都是必不可少的。这样,获得过渡金属是胃肠道中宿主-微生物相互作用的重要组成部分。在哺乳动物中,过渡金属离子经常被金属结合蛋白螯合,以限制稳态条件下微生物的进入。响应入侵的病原体,哺乳动物宿主通过调节其运输或释放高亲和力的金属螯合蛋白来进一步降低这些微量营养素的利用率,这一过程被称为营养免疫。细菌病原体已经进化出几种破坏营养免疫的机制。这里,
更新日期:2019-11-01
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