Fetal cutaneous wounds have the unique ability to completely regenerate wounded skin and heal without scarring. However, adult cutaneous wounds heal via a fibroproliferative response which results in the formation of a scar. Understanding the mechanism(s) of scarless wound healing leads to enormous clinical potential in facilitating an environment conducive to scarless healing in adult cutaneous wounds. This article reviews the embryonic development of the skin and outlines the structural and functional differences in adult and fetal wound healing phenotypes. A review of current developments made towards applying this clinical knowledge to promote scarless healing in adult wounds is addressed.

胎儿皮肤伤口具有独特的能力，可以使受伤的皮肤完全再生并愈合，不留疤痕。然而，成人皮肤伤口通过纤维增殖反应愈合，导致疤痕形成。了解无疤痕伤口愈合的机制在促进有利于成人皮肤伤口无疤痕愈合的环境方面具有巨大的临床潜力。本文回顾了皮肤的胚胎发育，并概述了成人和胎儿伤口愈合表型的结构和功能差异。回顾了应用这些临床知识促进成人伤口无疤痕愈合的当前进展。