Barrett's esophagus (BE) is the key precursor lesion of esophageal adenocarcinoma, a lethal cancer that has increased rapidly in westernized countries over the past four decades. Dietary sugar intake has also been increasing over time, and may be associated with these tumors by promoting hyperinsulinemia. The study goal was to examine multiple measures of sugar/starches intake in association with BE. This pooled analysis included 472 BE cases and 492 controls from two similarly conducted case-control studies in the United States. Dietary intake data, collected by study-specific food frequency questionnaires, were harmonized across studies by linking with the University of Minnesota Nutrient Database, and pooled based on study-specific quartiles. Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for age, sex, race, total energy intake, study indicator, body mass index, frequency of gastro-esophageal reflux, and fruit/vegetable intake. In both studies, intake of sucrose (cases vs. controls, g/day: 36.07 vs. 33.51; 36.80 vs. 35.06, respectively) and added sugar (46.15 vs. 41.01; 44.18 vs. 40.68, respectively) were higher in cases than controls. BE risk was increased 79% and 71%, respectively, for associations comparing the fourth to the first quartile of intake of sucrose (ORQ4vs.Q1 = 1.79, 95% CI = 1.07-3.02, P trend = 0.01) and added sugar (ORQ4vs.Q1 = 1.71, 95% CI = 1.05-2.80, P trend = 0.15). Intake of sweetened desserts/beverages was associated with 71% increase in BE risk (ORQ4vs.Q1 = 1.71, 95% CI = 1.07-2.73, P trend = 0.04). Limiting dietary intake of foods and beverages that are high in added sugar, especially refined table sugar, may reduce the risk of developing BE.

中文翻译：

---

膳食糖/淀粉摄入量和Barrett食道：汇总分析。

巴雷特食管（BE）是食道腺癌的主要前体病变，这是一种致命的癌症，在过去的四十年中在西方国家中迅速增加。饮食中糖的摄入量也随着时间的推移而增加，并且可能通过促进高胰岛素血症而与这些肿瘤相关。该研究目标是研究与BE相关的糖/淀粉摄入量的多种测量方法。该汇总分析包括来自美国两个类似进行的病例对照研究的472个BE病例和492个对照。通过研究特定食物频率调查表收集的膳食摄入数据，通过与明尼苏达大学营养数据库的链接在整个研究中得到统一，并根据研究特定四分位数进行汇总。使用Logistic回归计算比值比（OR）和95％置信区间（CI），调整年龄，性别，种族，总能量摄入，研究指标，体重指数，胃食管反流的频率以及水果/蔬菜摄入量。在两项研究中，蔗糖的摄入量（病例与对照组之间的比重，克/天：分别为36.07与33.51； 36.80与35.06；分别为46.15与41.01； 44.18与40.68）和添加糖的情况均高于病例控制。对于比较摄入蔗糖的第四至第一四分位数（ORQ4vs.Q1 = 1.79、95％CI = 1.07-3.02，P趋势= 0.01）和添加糖（ORQ4vs）的协会，BE风险分别增加了79％和71％ Q1 = 1.71，95％CI = 1.05-2.80，P趋势= 0.15）。摄入甜食/饮料会使BE风险增加71％（ORQ4vs.Q1 = 1.71，95％CI = 1.07-2.73，P趋势= 0.04）。限制饮食中高糖的食物和饮料的摄入量，