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Metabolic reprograming of anti-tumor immunity.
Current Opinion in Immunology ( IF 7 ) Pub Date : 2017-04-13 , DOI: 10.1016/j.coi.2017.03.011
Madhusudhanan Sukumar 1 , Rigel J Kishton 1 , Nicholas P Restifo 1
Affiliation  

Immunotherapies designed to trigger T cell destruction of tumor cells can result in sustained and complete responses in patients whose cancers were resistant to available treatment options. Evidence suggests that powering the T cell response - how T cells generate energy - plays an important role in their effectiveness. Furthermore the metabolism of T cells can be modulated to improve their anti-cancer activities. In this review, we will discuss the key metabolic properties of anti-cancer T cells, along with potential strategies to enhance immunotherapy through the modulation of T cell metabolism.

中文翻译:

抗肿瘤免疫的代谢重编程。

设计用于触发肿瘤细胞T细胞破坏的免疫疗法可导致癌症对可用治疗方案产生抗药性的患者持续而完全的反应。有证据表明,为T细胞反应提供动力-T细胞如何产生能量-在其有效性中起着重要作用。此外,可以调节T细胞的代谢以改善其抗癌活性。在这篇综述中,我们将讨论抗癌T细胞的关键代谢特性,以及通过调节T细胞代谢增强免疫疗法的潜在策略。
更新日期:2017-04-13
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