BACKGROUND We sought to determine whether formalin disinfection of prostate biopsy needles between cores reduces post-biopsy urinary tract infections (UTIs). METHODS We reviewed a single-surgeon experience of transrectal prostate biopsies from 2010 to 2014. Biopsies were performed in either an operative suite, where 10% formalin was used to disinfect the needle tip between each biopsy core, or an outpatient clinic, where formalin was not used. Our primary outcome was post-biopsy UTI rates, defined as a positive urine culture within 30 days of biopsy. Infection severity was characterized by the need for admission. Patient demographics, prostate size, prior biopsies, prior UTIs, pre-biopsy antibiotics and cultures and post-biopsy cultures were analyzed. Logistic regression was used to assess predictors of post-biopsy UTIs. Statistical significance was defined as P<0.05. RESULTS A total of 756 patients were included for analysis, including 253 who received formalin disinfection and 503 who did not. Of these, 32 patients (4.2%) experienced post-biopsy UTIs, with 8 requiring admission (all without formalin use). Infection rates were more than double in the group that did not receive formalin (5.2% vs 2.3%, P=0.085). More patients in the formalin group had undergone prior biopsies (73.9% vs 31.8%, P<0.001). On multivariable analysis, prior UTI (odds ratio (OR) 3.77, P=0.006) was a significant predictor for post-biopsy infection, whereas formalin disinfection trended towards a protective effect (OR 0.41, P=0.055). CONCLUSION Infectious complications following prostate biopsy may be mitigated by the use of formalin disinfection of the biopsy needle between cores.

中文翻译：

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前列腺活检针的福尔马林消毒可减少活检后的感染并发症。

背景技术我们试图确定在核心之间的前列腺活检针的福尔马林消毒是否减少了活检后的尿路感染（UTI）。方法我们回顾了2010年至2014年经直肠外穿刺活检的单手术经验。在一个手术室进行活检，其中10％的福尔马林用于消毒每个活检核心之间的针尖，在门诊则进行福尔马林的手术。未使用。我们的主要结果是活检后的UTI率，定义为活检30天内尿培养阳性。感染的严重程度以需要入院为特征。分析患者的人口统计学，前列腺大小，先前的活检，先前的UTI，活检前的抗生素和培养物以及活检后的培养物。Logistic回归用于评估活检后UTI的预测因子。统计学显着性定义为P <0.05。结果共纳入756例患者进行分析，其中253例接受了福尔马林消毒，而503例未接受福尔马林消毒。在这些患者中，有32位患者（4.2％）经历了活检后的UTI，其中8位患者需要入院（均不使用福尔马林使用）。没有接受福尔马林的组中感染率是原来的两倍以上（5.2％vs 2.3％，P = 0.085）。福尔马林组中有更多的患者接受过活检（73.9％比31.8％，P <0.001）。在多变量分析中，先前的尿路感染（优势比（OR）3.77，P = 0.006）是活检后感染的重要预测指标，而福尔马林消毒则具有保护作用（OR 0.41，P = 0.055）。结论前列腺穿刺活检后的感染并发症可通过对核心之间的穿刺活检针进行福尔马林消毒来减轻。