OBJECTIVE Thyroid hormone influences lipoprotein metabolism. The role of menopausal status in this association has not been extensively studied. The aim of the present study is to evaluate the association between lipid parameters and mild elevations of thyrotropin (TSH), and whether menopause influences this relationship. STUDY DESIGN A cross-sectional study was conducted with a sample of 2,914 women (aged 14-102 years) from the SardiNIA study. MAIN OUTCOME MEASURES The association of TSH with blood lipid levels was examined using regression analyses, according to menopausal status. RESULTS Postmenopausal women had lower serum TSH concentrations and higher levels of total cholesterol, low-density lipoprotein cholesterol (LDLc), high-density lipoprotein cholesterol (HDLc), and triglycerides than did premenopausal women (p=0.001 or less for all). In premenopausal women, after adjusting for the confounders age, BMI, smoking, insulin and glycaemia, TSH showed a direct relation to the levels of total cholesterol (β=0.046, p=0.010), LDLc (β=0.044, p=0.016) and triglycerides (β=0.085, p<0.001), but no association with HDLc level. In the postmenopausal group, TSH was directly associated only with triglyceride levels (β=0.103, p=0.014). CONCLUSIONS The association between mild elevation of TSH and lipid levels is influenced by menopausal status. Further research is needed to clarify this finding.

中文翻译：

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更年期调节促甲状腺激素水平与脂质参数之间的关联：SardiNIA 研究

目的 甲状腺激素影响脂蛋白代谢。更年期状态在这种关联中的作用尚未得到广泛研究。本研究的目的是评估脂质参数与促甲状腺激素 (TSH) 轻度升高之间的关联，以及更年期是否影响这种关系。研究设计 对来自 SardiNIA 研究的 2,914 名女性（14-102 岁）样本进行了横断面研究。主要结局指标根据更年期状态，使用回归分析检查 TSH 与血脂水平的关联。结果与绝经前妇女相比，绝经后妇女的血清 TSH 浓度较低，总胆固醇、低密度脂蛋白胆固醇 (LDLc)、高密度脂蛋白胆固醇 (HDLc) 和甘油三酯水平较高（p = 0.001 或更低）。在绝经前女性中，在调整混杂因素年龄、BMI、吸烟、胰岛素和血糖后，TSH 显示与总胆固醇 (β=0.046, p=0.010)、LDLc (β=0.044, p=0.016) 水平直接相关和甘油三酯（β=0.085，p<0.001），但与 HDLc 水平无关。在绝经后组中，TSH 仅与甘油三酯水平直接相关（β=0.103，p=0.014）。结论 TSH 轻度升高与脂质水平之间的关联受更年期状态的影响。需要进一步的研究来澄清这一发现。在绝经后组中，TSH 仅与甘油三酯水平直接相关（β=0.103，p=0.014）。结论 TSH 轻度升高与脂质水平之间的关联受更年期状态的影响。需要进一步的研究来澄清这一发现。在绝经后组中，TSH 仅与甘油三酯水平直接相关（β=0.103，p=0.014）。结论 TSH 轻度升高与脂质水平之间的关联受更年期状态的影响。需要进一步的研究来澄清这一发现。