Telomeres function in the context of a complex nuclear milieu in which telomeres tend to occupy distinct subnuclear regions. Indeed, regulation of the subnuclear positioning of telomeres is conserved from yeast to human, raising the age-old question: to what extent is location important for function? In mitotically dividing cells, the positioning of telomeres affects their epigenetic state and influences telomere processing and synthesis. In meiotic cells, telomere location is important for homologue pairing, centromere assembly and spindle formation. Here we focus on recent insights into the functions of telomere positioning in maintaining genome integrity.

中文翻译：

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在SUN中找到位置：在各种核环境中进行端粒维护。

端粒在复杂的核环境中发挥作用，其中端粒倾向于占据不同的亚核区域。确实，从酵母到人，对端粒亚核位置的调节是保守的，这引发了一个古老的问题：位置对功能的重要程度是什么？在有丝分裂的细胞中，端粒的定位影响其表观遗传状态，并影响端粒的加工和合成。在减数分裂细胞中，端粒位置对于同源配对，着丝粒组装和纺锤体形成很重要。在这里，我们专注于端粒定位在维持基因组完整性中的功能的最新见解。