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The role of microbiota in cancer therapy.
Current Opinion in Immunology ( IF 7 ) Pub Date : 2016-01-29 , DOI: 10.1016/j.coi.2016.01.003 Ernesto Perez-Chanona 1 , Giorgio Trinchieri 2
Current Opinion in Immunology ( IF 7 ) Pub Date : 2016-01-29 , DOI: 10.1016/j.coi.2016.01.003 Ernesto Perez-Chanona 1 , Giorgio Trinchieri 2
Affiliation
The relationship between the host and the commensal microbiota regulates physiological functions including inflammation and immunity and it has been scrutinized in the context of cancer. While viruses and bacterial species have been implicated in oncogenesis, commensal microbes also have a beneficial role in the fight against cancer. Therapy efficacy, including adoptive T cell transfer, alkylating agents and immune checkpoint blockers, relies on immunity that receives its education from the gut microbiota. In cancer therapy with immunostimulating oligonucleotides and platinum salts, the microbiota also modulates the response by priming for the release of pro-inflammatory factors and reactive oxygen species, respectively. This new information offers promising clinical possibilities of modulating cancer therapy and its toxic side effects by targeting the microbiota.
中文翻译:
微生物群在癌症治疗中的作用。
宿主与共生菌群之间的关系调节着包括炎症和免疫力在内的生理功能,在癌症的背景下已经进行了仔细的研究。尽管病毒和细菌物种与肿瘤发生有关,但共生微生物在对抗癌症方面也具有有益作用。包括过继性T细胞转移,烷基化剂和免疫检查点阻滞剂在内的治疗功效依赖于从肠道菌群获得教育的免疫力。在用免疫刺激性寡核苷酸和铂盐进行的癌症治疗中,微生物群还分别通过引发促炎因子和活性氧的释放来调节反应。
更新日期:2016-01-26
中文翻译:
微生物群在癌症治疗中的作用。
宿主与共生菌群之间的关系调节着包括炎症和免疫力在内的生理功能,在癌症的背景下已经进行了仔细的研究。尽管病毒和细菌物种与肿瘤发生有关,但共生微生物在对抗癌症方面也具有有益作用。包括过继性T细胞转移,烷基化剂和免疫检查点阻滞剂在内的治疗功效依赖于从肠道菌群获得教育的免疫力。在用免疫刺激性寡核苷酸和铂盐进行的癌症治疗中,微生物群还分别通过引发促炎因子和活性氧的释放来调节反应。