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Sizing up to divide: mitotic cell-size control in fission yeast.
Annual Review of Cell and Developmental Biology ( IF 11.3 ) Pub Date : 2015-11-14 , DOI: 10.1146/annurev-cellbio-100814-125601
Elizabeth Wood 1 , Paul Nurse
Affiliation  

Schizosaccharomyces pombe is a good model to study cell-size control. These cells integrate size information into cell cycle controls at both the G1/S and G2/M transitions, although the primary control operates at the entry into mitosis. At G2/M there is both a size threshold, demonstrated by the fact that cells divide when they reach 14 μm in length, and also correction around this threshold, evident from the narrow distribution of sizes within a population. This latter property is referred to as size homeostasis. It has been argued that a population of cells accumulating mass in a linear fashion will have size homeostasis in the absence of size control, if cycle time is controlled by a fixed timer. Because fission yeast cells do not grow in a simple linear fashion, they require a size-sensing mechanism. However, current models do not fully describe all aspects of this control, especially the coordination of cell size with ploidy.

中文翻译:

大小划分:裂变酵母中有丝分裂细胞大小的控制。

裂殖酵母是研究细胞大小控制的良好模型。这些细胞将大小信息整合到G1 / S和G2 / M转换的细胞周期控制中,尽管主要控制在进入有丝分裂时起作用。在G2 / M处,既有一个大小阈值,这由以下事实证明:当细胞长度达到14μm时会分裂,并且在此阈值附近进行校正,这可从种群中大小的狭窄分布中看出。后一种属性称为大小动态平衡。有人认为,如果周期时间是由固定的计时器控制的,那么在没有大小控制的情况下,以线性方式积累质量的细胞群体将具有大小稳态。由于裂变酵母细胞不能以简单的线性方式生长,因此它们需要大小感应机制。然而,
更新日期:2015-11-13
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