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Lipid droplet-organelle interactions: emerging roles in lipid metabolism.
Current Opinion in Cell Biology ( IF 7.5 ) Pub Date : 2015-05-20 , DOI: 10.1016/j.ceb.2015.04.017
Antonio Daniel Barbosa 1 , David B Savage 2 , Symeon Siniossoglou 1
Affiliation  

Cellular homeostasis depends on the precisely coordinated use of lipids as fuels for energy production, building blocks for membrane biogenesis or chemical signals for intra-cellular and inter-cellular communication. Lipid droplets (LDs) are universally conserved dynamic organelles that can store and mobilize fatty acids and other lipid species for their multiple cellular roles. Increasing evidence suggests that contact zones between LDs and other organelles play important roles in the trafficking of lipids and in the regulation of lipid metabolism. Here we review recent advances regarding the nature and functional relevance of interactions between LDs and other organelles-particularly the endoplasmic reticulum (ER), LDs, mitochondria and vacuoles-that highlight their importance for lipid metabolism.

中文翻译:

脂滴 - 细胞器相互作用:脂质代谢中的新作用。

细胞稳态依赖于精确协调使用脂质作为能量产生的燃料、膜生物发生的基石或细胞内和细胞间通讯的化学信号。脂滴 (LD) 是普遍保守的动态细胞器,可以储存和调动脂肪酸和其他脂质种类,以发挥其多种细胞作用。越来越多的证据表明,LDs 和其他细胞器之间的接触区在脂质运输和脂质代谢的调节中起着重要作用。在这里,我们回顾了有关 LD 与其他细胞器之间相互作用的性质和功能相关性的最新进展 - 特别是内质网 (ER)、LD、线粒体和液泡 - 突出了它们对脂质代谢的重要性。
更新日期:2015-05-15
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