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Exceptionally widespread nanomachines composed of type IV pilins: the prokaryotic Swiss Army knives.
FEMS Microbiology Reviews ( IF 11.3 ) Pub Date : 2015-03-21 , DOI: 10.1093/femsre/fuu001
Jamie-Lee Berry 1 , Vladimir Pelicic 2
Affiliation  

Prokaryotes have engineered sophisticated surface nanomachines that have allowed them to colonize Earth and thrive even in extreme environments. Filamentous machineries composed of type IV pilins, which are associated with an amazing array of properties ranging from motility to electric conductance, are arguably the most widespread since distinctive proteins dedicated to their biogenesis are found in most known species of prokaryotes. Several decades of investigations, starting with type IV pili and then a variety of related systems both in bacteria and archaea, have outlined common molecular and structural bases for these nanomachines. Using type IV pili as a paradigm, we will highlight in this review common aspects and key biological differences of this group of filamentous structures.

中文翻译:

由IV型菌毛蛋白组成的异常广泛的纳米机器:原核瑞士军刀。

原核生物设计了复杂的表面纳米机器,使它们能够在地球上殖民并即使在极端环境中也能茁壮成长。由 IV 型菌毛蛋白组成的丝状机械具有从运动性到电导等一系列惊人的特性,可以说是最普遍的,因为在大多数已知的原核生物物种中都发现了专门用于其生物发生的独特蛋白质。几十年的研究,从 IV 型菌毛开始,然后是细菌和古细菌中的各种相关系统,已经概述了这些纳米机器的常见分子和结构基础。以 IV 型菌毛为范例,我们将在这篇综述中强调这组丝状结构的共同方面和关键生物学差异。
更新日期:2014-11-26
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