当前位置:
X-MOL 学术
›
Immunol. Rev.
›
论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Cytokine and lipid mediator networks in tuberculosis.
Immunological Reviews ( IF 8.7 ) Pub Date : 2015-02-24 , DOI: 10.1111/imr.12249 Katrin D Mayer-Barber 1 , Alan Sher
Immunological Reviews ( IF 8.7 ) Pub Date : 2015-02-24 , DOI: 10.1111/imr.12249 Katrin D Mayer-Barber 1 , Alan Sher
Affiliation
A major approach for immunologic intervention in tuberculosis involves redirecting the outcome of the host immune response from the induction of disease to pathogen control. Cytokines and lipid mediators known as eicosanoids play key roles in regulating this balance and as such represent important targets for immunologic intervention. While the evidence for cytokine/eicosanoid function derives largely from the investigation of murine and zebrafish experimental infection models, clinical studies have confirmed the existence of many of the same pathways in tuberculosis patients. Here, we summarize new data that reveal important intersections between the cytokine and eicosanoid networks in the host response to mycobacteria and discuss how targeting this crosstalk can promote resistance to lethal Mycobacterium tuberculosis infection. This approach could lead to new host-directed therapies to be used either as an adjunct for improving the efficacy of standard antibiotic treatment or for the management of drug-resistant infections.
中文翻译:
结核中的细胞因子和脂质介体网络。
结核病免疫干预的一种主要方法涉及将宿主免疫应答的结果从疾病诱导重定向到病原体控制。被称为类花生酸的细胞因子和脂质介体在调节这种平衡中起关键作用,因此是免疫干预的重要靶标。虽然细胞因子/类花生酸功能的证据主要来自鼠和斑马鱼实验性感染模型的研究,但临床研究已证实结核病患者中存在许多相同的途径。在这里,我们总结了一些新数据,这些数据揭示了宿主对分枝杆菌反应中细胞因子和类二十烷酸网络之间的重要交集,并讨论了针对这种串扰如何提高对致死性结核分枝杆菌感染的抵抗力。
更新日期:2015-02-20
中文翻译:
结核中的细胞因子和脂质介体网络。
结核病免疫干预的一种主要方法涉及将宿主免疫应答的结果从疾病诱导重定向到病原体控制。被称为类花生酸的细胞因子和脂质介体在调节这种平衡中起关键作用,因此是免疫干预的重要靶标。虽然细胞因子/类花生酸功能的证据主要来自鼠和斑马鱼实验性感染模型的研究,但临床研究已证实结核病患者中存在许多相同的途径。在这里,我们总结了一些新数据,这些数据揭示了宿主对分枝杆菌反应中细胞因子和类二十烷酸网络之间的重要交集,并讨论了针对这种串扰如何提高对致死性结核分枝杆菌感染的抵抗力。