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Noncoding RNA in age-related cardiovascular diseases.
Journal of Molecular and Cellular Cardiology ( IF 5 ) Pub Date : 2015-01-29 , DOI: 10.1016/j.yjmcc.2015.01.011
Simona Greco 1 , Myriam Gorospe 2 , Fabio Martelli 1
Affiliation  

Eukaryotic gene expression is tightly regulated transcriptionally and post-transcriptionally by a host of noncoding (nc)RNAs. The best-studied class of short ncRNAs, microRNAs, mainly repress gene expression post-transcriptionally. Long noncoding (lnc)RNAs, which comprise RNAs differing widely in length and function, can regulate gene transcription as well as post-transcriptional mRNA fate. Collectively, ncRNAs affect a broad range of age-related physiologic deteriorations and pathologies, including reduced cardiovascular vigor and age-associated cardiovascular disease. This review presents an update of our understanding of regulatory ncRNAs contributing to cardiovascular health and disease as a function of advancing age. We will discuss (1) regulatory ncRNAs that control aging-associated cardiovascular homeostasis and disease, (2) the concepts, approaches, and methodologies needed to study regulatory ncRNAs in cardiovascular aging and (3) the challenges and opportunities that age-associated regulatory ncRNAs present in cardiovascular physiology and pathology. This article is part of a Special Issue entitled "CV Aging".

中文翻译:

与年龄相关的心血管疾病中的非编码 RNA。

真核基因表达在转录和转录后受到大量非编码 (nc) RNA 的严格调控。研究得最好的一类短 ncRNA,即 microRNA,主要在转录后抑制基因表达。长链非编码 (lnc) RNA 包含长度和功能差异很大的 RNA,可以调节基因转录以及转录后 mRNA 的命运。总的来说,ncRNA 会影响广泛的与年龄相关的生理恶化和病理,包括心血管活力降低和与年龄相关的心血管疾病。本综述更新了我们对随着年龄增长而促进心血管健康和疾病的调节性 ncRNA 的理解。我们将讨论(1)控制与衰老相关的心血管稳态和疾病的调节性 ncRNA,(2)概念,研究心血管衰老中调节性 ncRNA 所需的方法和方法,以及 (3) 与年龄相关的调节性 ncRNA 在心血管生理学和病理学中存在的挑战和机遇。本文是题为“CV 老化”的特刊的一部分。
更新日期:2015-01-29
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