Globally, endometrial carcinoma causes about 74000 deaths annually. Endometrial carcinomas can be classified into several histological subtypes including endometrioid and serous histologies. Over the course of the past two years, a number of studies have decoded the exomes of endometrioid and serous endometrial carcinomas revealing novel somatically mutated genes that are likely to drive their development. Moreover, an integrated genomic analysis of these two histological subtypes by The Cancer Genome Atlas has led to their molecular reclassification into four discrete molecular subgroups. Collectively, these genomic advances set the stage for future biological and clinical studies to determine their relevance for patient care.

中文翻译：

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子宫内膜癌的突变情况。

在全球范围内，子宫内膜癌每年导致约74000人死亡。子宫内膜癌可分为几种组织学亚型，包括子宫内膜样和浆液性组织学。在过去的两年中，许多研究对子宫内膜样癌和浆液性子宫内膜癌的外显子组进行了解码，揭示了可能推动其发展的新型体细胞突变基因。此外，《癌症基因组图谱》对这两种组织学亚型的综合基因组分析已将其分子重新分类为四个离散的分子亚组。总的来说，这些基因组学的进步为未来的生物学和临床研究奠定了基础，以确定它们与患者护理的相关性。