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Mitochondrial pyruvate import and its effects on homeostasis.
Current Opinion in Cell Biology ( IF 7.5 ) Pub Date : 2014-12-03 , DOI: 10.1016/j.ceb.2014.10.008
Benoît Vanderperre 1 , Tom Bender 1 , Edmund R S Kunji 2 , Jean-Claude Martinou 1
Affiliation  

Pyruvate metabolism plays a pivotal role in cell homeostasis and energy production. Pyruvate, the end product of glycolysis, is either catabolized in the cytosol, or enters into mitochondria to promote oxidative phosphorylation. The import of pyruvate into mitochondria requires a specific carrier in the inner mitochondrial membrane, the mitochondrial pyruvate carrier (MPC), whose identity was only recently discovered. Here we report our current knowledge of the structure and function of the MPC and we describe how dysfunction of the MPC could participate in various pathologies, including type 2 diabetes and cancer.

中文翻译:

线粒体丙酮酸输入及其对体内平衡的影响。

丙酮酸代谢在细胞稳态和能量产生中起关键作用。丙酮酸是糖酵解的最终产物,要么在胞质溶胶中分解代谢,要么进入线粒体以促进氧化磷酸化。丙酮酸进入线粒体需要线粒体内膜中的特定载体,即线粒体丙酮酸载体 (MPC),其身份最近才被发现。在这里,我们报告了我们目前对 MPC 的结构和功能的了解,并描述了 MPC 的功能障碍如何参与各种病理,包括 2 型糖尿病和癌症。
更新日期:2014-11-15
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