CD4 T cells are critical for control of Mycobacterium tuberculosis (Mtb) infection and represent the best hope for vaccine-elicited protection. However, little is understood about the properties of Mtb-specific CD4 T cells that mediate control, and the lack of correlates of protection present a significant barrier to the rational development of new vaccination and therapeutic strategies which are sorely needed. Here we discuss the features of protective CD4 T cells including recent evidence for IFN-γ dependent and independent mechanisms of protection, poor protection by terminally differentiated cells and the importance of T cell migratory capacity for the control of Mtb infection.

中文翻译：

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对结核分枝杆菌的保护性 CD4 T 细胞反应的定义特征。

CD4 T 细胞对于控制结核分枝杆菌 (Mtb) 感染至关重要，代表了疫苗引发保护的最佳希望。然而，对介导控制的 Mtb 特异性 CD4 T 细胞的特性知之甚少，并且缺乏保护相关性对合理开发迫切需要的新疫苗接种和治疗策略构成了重大障碍。在这里，我们讨论了保护性 CD4 T 细胞的特征，包括最近关于 IFN-γ 依赖性和独立保护机制的证据、终末分化细胞的保护性差以及 T 细胞迁移能力对控制 Mtb 感染的重要性。