Uterine leiomyomas (fibroids, myomas) are the most common benign tumors of female reproductive tract. They are highly prevalent, with 70–80% of women burdened by the end of their reproductive years. Fibroids are a leading cause of pelvic pain, abnormal vaginal bleeding, pressure on the bladder, miscarriage, and infertility. They are the leading indication for hysterectomy, and costs exceed 6 billion dollars annually in the United States. Unfortunately, no long‐term medical treatments are available. Dysregulation of inflammatory processes are thought to be involved in the initiation of leiomyoma and extracellular matrix deposition, cell proliferation, and angiogenesis are the key cellular events implicated in leiomyoma growth. In modern pharmaceutical industries, dietary phytochemicals are used as source of new potential drugs for many kinds of tumors. Dietary phytochemicals may exert therapeutic effects by interfering with key cellular events of the tumorigenesis process. At present, a negligible number of phytochemicals have been tested as therapeutic agents against fibroids. In this context, our aim was to introduce some of the potential dietary phytochemicals that have shown anti‐inflammatory, antiproliferative, antifibrotic, and antiangiogenic activities in different biological systems. This review could be useful to stimulate the evaluation of these phytochemicals as possible therapies for uterine fibroids.

中文翻译：

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使用膳食植物化学物质来靶向子宫组织中的炎症、纤维化、增殖和血管生成：预防和治疗子宫肌瘤的有希望的选择？

子宫平滑肌瘤（纤维瘤、肌瘤）是女性生殖道最常见的良性肿瘤。它们非常普遍，70-80% 的妇女在生育年龄结束时承受着负担。肌瘤是导致骨盆疼痛、阴道异常出血、膀胱压力、流产和不孕症的主要原因。它们是子宫切除术的主要适应症，在美国每年花费超过 60 亿美元。不幸的是，没有长期的药物治疗可用。炎症过程的失调被认为与平滑肌瘤的发生有关，细胞外基质沉积、细胞增殖和血管生成是与平滑肌瘤生长有关的关键细胞事件。在现代制药工业中，膳食植物化学物质被用作治疗多种肿瘤的新潜在药物的来源。膳食植物化学物质可能通过干扰肿瘤发生过程的关键细胞事件来发挥治疗作用。目前，已经测试了可忽略不计数量的植物化学物质作为针对肌瘤的治疗剂。在这种情况下，我们的目的是介绍一些潜在的膳食植物化学物质，它们在不同的生物系统中显示出抗炎、抗增殖、抗纤维化和抗血管生成活性。该综述可能有助于促进对这些植物化学物质作为子宫肌瘤的可能疗法的评估。已经测试了可忽略不计数量的植物化学物质作为抗肌瘤的治疗剂。在这种情况下，我们的目的是介绍一些潜在的膳食植物化学物质，它们在不同的生物系统中显示出抗炎、抗增殖、抗纤维化和抗血管生成活性。该综述可能有助于促进对这些植物化学物质作为子宫肌瘤的可能疗法的评估。已经测试了可忽略不计数量的植物化学物质作为抗肌瘤的治疗剂。在这种情况下，我们的目的是介绍一些潜在的膳食植物化学物质，它们在不同的生物系统中显示出抗炎、抗增殖、抗纤维化和抗血管生成活性。该综述可能有助于促进对这些植物化学物质作为子宫肌瘤的可能疗法的评估。