While the discovery of B-form DNA 60 years ago has defined our molecular view of the genetic code, other postulated DNA secondary structures, such as A-DNA, Z-DNA, H-DNA, cruciform and slipped structures have provoked consideration of DNA as a more dynamic structure. Four-stranded G-quadruplex DNA does not use Watson-Crick base pairing and has been subject of considerable speculation and investigation during the past decade, particularly with regard to its potential relevance to genome integrity and gene expression. Here, we discuss recent data that collectively support the formation of G-quadruplexes in genomic DNA and the consequences of formation of this structural motif in biological processes.

中文翻译：

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DNA中G-四链体结构的存在和后果。

虽然 60 年前 B 型 DNA 的发现定义了我们对遗传密码的分子观点，但其他假定的 DNA 二级结构，如 A-DNA、Z-DNA、H-DNA、十字形和滑动结构也引发了对 DNA 的考虑作为一个更动态的结构。四链 G-四链体 DNA 不使用 Watson-Crick 碱基配对，在过去十年中一直是大量推测和研究的主题，特别是在其与基因组完整性和基因表达的潜在相关性方面。在这里，我们讨论了最近的数据，这些数据共同支持基因组 DNA 中 G-四链体的形成以及这种结构基序在生物过程中形成的后果。