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Impact of body size and physical activity during adolescence and adult life on overall and cause-specific mortality in a large cohort study from Iran.
European Journal of Epidemiology ( IF 13.6 ) Pub Date : 2014-02-22 , DOI: 10.1007/s10654-014-9883-6
Arash Etemadi 1 , Christian C Abnet , Farin Kamangar , Farhad Islami , Hooman Khademi , Akram Pourshams , Hossein Poustchi , Mohammad Bagheri , Amir Ali Sohrabpour , Ali Aliasgar , Masoud Khoshnia , Sholom Wacholder , Charles C Matthews , Paul D Pharoah , Paul Brennan , Paolo Boffetta , Reza Malekzadeh , Sanford M Dawsey
Affiliation  

We conducted this study to examine life-course body size and physical activity in relation to total and cause-specific mortality, which has not previously been studied in the low and middle-income countries in Asia. The Golestan Cohort Study is a population-based cohort in northeastern Iran in which 50,045 people above the age of 40 have been followed since 2004. Participants were shown a validated pictogram to assess body size at ages 15, 30, and the time of recruitment. Information on occupational physical activity at these ages was also collected. Subjects were followed up annually, and cause of death was determined. Cox regression models were adjusted for age at cohort start, smoking, socioeconomic status, ethnicity, place of residence, education, and opium use. Models for body size were also adjusted for physical activity at the same age, and vice versa. During a total of 252,740 person-years of follow-up (mean follow-up duration 5.1 ± 1.3 years) through December 2011, 2,529 of the cohort participants died. Larger body sizes at ages 15 or 30 in both sexes were associated with increased overall mortality. Cancer mortality was more strongly associated with adolescent obesity, and cardiovascular mortality with early adulthood body size. Weight gain between these ages was associated with cardiovascular mortality. Obese adolescents who lost weight still had increased mortality from all medical causes in both sexes. Physical activity during adolescence and early adulthood had no association with mortality, but at cohort baseline higher levels of activity were associated with reduced mortality. Mortality in this Middle-Eastern population was associated with obesity both during adolescence and early adult life.

中文翻译:

在伊朗的一项大型队列研究中,青春期和成年期的体型和身体活动对总体死亡率和特定原因死亡率的影响。

我们进行了这项研究,以检查生命过程中的身体大小和身体活动与总死亡率和特定原因死亡率的关系,这在亚洲低收入和中等收入国家之前尚未进行过研究。Golestan 队列研究是伊朗东北部的一项基于人群的队列研究,自 2004 年以来对 50,045 名 40 岁以上的人进行了随访。向参与者展示了经过验证的象形图,以评估 15、30 岁和招募时间的体型。还收集了这些年龄段的职业体育活动信息。每年对受试者进行随访,并确定死因。Cox 回归模型根据队列开始时的年龄、吸烟、社会经济地位、种族、居住地、教育和鸦片使用情况进行了调整。体型模型也根据同龄的体力活动进行了调整,反之亦然。在截至 2011 年 12 月的总共 252,740 人年的随访期间(平均随访时间为 5.1 ± 1.3 年),2,529 名队列参与者死亡。男女在 15 或 30 岁时体型较大与总体死亡率增加有关。癌症死亡率与青少年肥胖和心血管死亡率与成年早期体型的相关性更强。这些年龄之间的体重增加与心血管死亡率有关。无论男女,体重减轻的肥胖青少年因各种医学原因导致的死亡率仍然增加。青春期和成年早期的体力活动与死亡率无关,但在队列基线时,较高的活动水平与死亡率降低相关。
更新日期:2014-02-21
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