Multiple intracellular RNA sensing innate immune pathways have been linked to autoimmune disease. RNA-related ligands taken up by the endocytic pathway activate TLRs, and affect primarily immune cells. This type of activation is enhanced by nucleic acid-specific antibodies and induces an inflammatory program. In contrast, spontaneous activation of cytoplasmic RNA sensing pathways targets mostly non-hematopoietic tissues and their effect on autoimmune disease is secondary to the release of interferon in the circulation. The fact that pathologies result from spontaneous activation of innate pathways implies that endogenous RNA ligands that might be sensed as pathogenic are commonly found in both immune and non-immune cells.

中文翻译：

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自身免疫性疾病中 RNA 传感途径的自发激活。

多种细胞内 RNA 感应先天免疫通路与自身免疫性疾病有关。内吞途径吸收的 RNA 相关配体激活 TLR，主要影响免疫细胞。这种类型的激活由核酸特异性抗体增强并诱导炎症程序。相比之下，细胞质 RNA 传感途径的自发激活主要针对非造血组织，它们对自身免疫性疾病的影响是继发于循环中干扰素的释放。病理是由先天途径的自发激活引起的，这一事实意味着可能被感知为致病性的内源性 RNA 配体通常存在于免疫和非免疫细胞中。