Impulsive-compulsive behaviors (ICBs) in Parkinson's disease (PD) are a common and devastating side effect of dopamine replacement therapy. In this review we describe the phenomenology, prevalence, and risk factors of patients with PD. Results of behavioral studies assessing the neuropsychological profile of patients with PD emphasize that the ICBs, which are behavioral addictions, are not hedonically motivated. Rather, other factors such as the inability to cope with uncertainty may be triggering ICBs. New insights from functional imaging studies, strengthening the incentive salience hypothesis, are discussed, and therapeutic guidelines for the management of ICBs in PD are given.

中文翻译：

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帕金森病的冲动和强迫行为。

帕金森病 (PD) 中的冲动行为 (ICB) 是多巴胺替代疗法常见且具有破坏性的副作用。在这篇综述中，我们描述了 PD 患者的现象学、患病率和危险因素。评估 PD 患者神经心理特征的行为研究结果强调，行为成瘾的 ICB 不是享乐动机。相反，其他因素，例如无法应对不确定性，可能会触发 ICB。讨论了功能成像研究的新见解，加强了激励显着性假设，并给出了 PD 中 ICB 管理的治疗指南。