Systemic lupus erythematosus is a complex autoimmune disease of multifactorial origins. All compartments of the immune system appear to be affected, at least in some way, and to contribute to disease pathogenesis. Because of an escape from negative selection autoreactive T and B cells accumulate in SLE patients leading to the production of autoantibodies mainly raised against nuclear components and their subsequent deposition into target organs. We recently showed that basophils, in an IgE and IL-4 dependent manner, contribute to SLE pathogenesis by amplifying autoantibody production. Here, we summarize what we have learned about the deleterious role of basophils in lupus both in a mouse model and in SLE patients. We discuss which possible pathways could be involved in basophil activation and recruitment to secondary lymphoid organs during SLE, and how basophils may amplify autoantibody production.

中文翻译：

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嗜碱性粒细胞在系统性红斑狼疮中的有害作用。

系统性红斑狼疮是一种复杂的多因素自身免疫性疾病。免疫系统的所有部分似乎都受到影响，至少在某种程度上，并有助于疾病的发病机制。由于逃避负选择，自身反应性 T 和 B 细胞在 SLE 患者中积累，导致产生主要针对核成分的自身抗体，并随后沉积到靶器官中。我们最近表明嗜碱性粒细胞以 IgE 和 IL-4 依赖性方式通过放大自身抗体的产生促进 SLE 发病机制。在这里，我们总结了我们所了解的嗜碱性粒细胞在小鼠模型和 SLE 患者中对狼疮的有害作用。我们讨论了哪些可能的途径可能参与 SLE 期间嗜碱性粒细胞的激活和向次级淋巴器官的募集，