Styrene acrylonitrile (SAN) trimer is a by-product in the production of acrylonitrile styrene plastics. Following a report of a childhood cancer cluster in the Toms River section of Dover Township, New Jersey, SAN Trimer was identified as one of the groundwater contaminants at Reich Farm Superfund site in the township. The contaminants from the Reich Farm site's ground water plume impacted two wells at the Parkway well field. The National Toxicology Program (NTP) studied the toxicity and carcinogenicity of SAN Trimer in rats exposed during their perinatal developmental period and adulthood. The chronic toxicity and carcinogenicity studies in F344/N rats were preceded by 7- and 18-week perinatal toxicity studies to determine the exposure concentrations for the 2-year studies. Subsequently, Fisher 344 pregnant dams were exposed to SAN Trimer containing diet at 400, 800, or 1600ppm concentrations during gestation, nursing and weaning periods of offspring followed by two year of adult exposures to both male and female pups. There was no statistically significant evidence of carcinogenic activity following SAN-Trimer exposure; however, rare neoplasms in the brain and spinal cord were observed in males and to lesser extent in female rats. These incidences were considered within the range of historical background in the animal model used in the current studies. Therefore, the presence of a few rarely occurring CNS tumors in the treated groups were not judged to be associated with the SAN Trimer exposure. The major finding was a dose-related peripheral neuropathy associated with the sciatic nerves in females and spinal nerve roots in males and females thereby suggesting that SAN Trimer is potentially a nervous system toxicant.

中文翻译：

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苯乙烯-丙烯腈三聚体（一种地下水污染物）的围产期毒性和致癌性研究。

苯乙烯丙烯腈 (SAN) 三聚体是丙烯腈苯乙烯塑料生产过程中的副产品。根据新泽西州多佛镇汤姆斯河段儿童癌症集群的报告，SAN Trimer 被确定为该镇 Reich Farm Superfund 站点的地下水污染物之一。来自 Reich Farm 场地地下水羽流的污染物影响了 Parkway 井场的两口井。国家毒理学计划 (NTP) 研究了 SAN Trimer 对围产期发育期和成年期暴露的大鼠的毒性和致癌性。F344/N 大鼠的慢性毒性和致癌性研究之前进行了 7 周和 18 周的围产期毒性研究，以确定 2 年研究的暴露浓度。随后，在后代的妊娠、哺乳和断奶期间，Fisher 344 怀孕母猪暴露于含有 400、800 或 1600 ppm 浓度的 SAN Trimer 的饮食中，随后成年暴露于雄性和雌性幼崽两年。SAN-Trimer 暴露后没有统计学上显着的致癌活性证据；然而，在雄性大鼠中观察到罕见的脑和脊髓肿瘤，在雌性大鼠中观察到的程度较小。这些发生率被认为在当前研究中使用的动物模型的历史背景范围内。因此，治疗组中少数罕见的 CNS 肿瘤的存在被认为与 SAN Trimer 暴露无关。