There is a growing appreciation that metabolic signals are integrated and coupled to cell cycle progression. However, the molecular wiring that connects nutrient availability, biosynthetic intermediates and energetic balance to the core cell cycle machinery remains incompletely understood. In this review, we explore the recent progress in this area with particular emphasis on how nutrient and energetic status is sensed within the cell to ultimately regulate cell growth and division. The role these pathways play in normal cell function including stem cell biology is also discussed. Furthermore, we describe the growing appreciation that dysregulation of these pathways might contribute to a variety of pathological conditions including metabolic diseases and tumor formation.

中文翻译：

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细胞周期的代谢调节。

人们越来越认识到代谢信号被整合并与细胞周期进程耦合。然而，将营养可用性、生物合成中间体和能量平衡与核心细胞周期机制联系起来的分子线路仍未完全了解。在这篇综述中，我们探讨了该领域的最新进展，特别强调如何在细胞内感知营养和能量状态以最终调节细胞生长和分裂。还讨论了这些途径在包括干细胞生物学在内的正常细胞功能中所起的作用。此外，我们描述了越来越多的人认识到这些途径的失调可能导致各种病理状况，包括代谢疾病和肿瘤形成。