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Transient receptor potential channels and mechanosensation.
Annual Review of Neuroscience ( IF 13.9 ) Pub Date : 2013-07-08 , DOI: 10.1146/annurev-neuro-062012-170412
Niels Eijkelkamp 1 , Kathryn Quick , John N Wood
Affiliation  

Transient receptor potential (TRP) channels act as sensors for a range of stimuli as diverse as light, sound, touch, pheromones, and tissue damage. Their role in mechanosensation in the animal kingdom, identified by gene ablation studies, has raised questions about whether they are directly mechanically gated, whether they act alone or in concert with other channels to transduce mechanical stimuli, and their relative importance in various functions and disease states in humans. The ability of these channels to form heteromultimers and interact with other ion channels underlies a range of cell-specific functions in different cell types. Here we overview recent advances in this rapidly expanding field, focusing on somatosensation, hearing, the cardiovascular system, and interactions between TRP channels and other proteins involved in mechanoelectrical signaling.

中文翻译:

瞬时受体电位通道和机械感觉。

瞬态受体电位 (TRP) 通道充当传感器,用于各种刺激,如光、声音、触觉、信息素和组织损伤。通过基因消融研究确定,它们在动物界的机械感觉中的作用提出了以下问题:它们是否是直接机械门控的,它们是单独作用还是与其他通道协同作用以传导机械刺激,以及它们在各种功能和疾病中的相对重要性人类的状态。这些通道形成异多聚体并与其他离子通道相互作用的能力是不同细胞类型中一系列细胞特异性功能的基础。在这里,我们概述了这一迅速发展的领域的最新进展,重点关注躯体感觉、听力、心血管系统、
更新日期:2013-07-10
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