Immunity to intracellular pathogens and cancer relies on the generation of robust CD8(+) T cell effector responses as well as the establishment of immunological memory. During a primary immune response CD8(+) T cells experience diverse extracellular environmental cues and cell-cell interactions that trigger downstream transcriptional programs ultimately guiding a CD8(+) T cell to undertake either an effector or a memory cell fate. Here, we discuss our current understanding of the signaling pathways and transcriptional networks that regulate effector and memory commitment in CD8(+) T lymphocytes.

中文翻译：

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效应子和记忆 CD8+ T 细胞命运的转录调控。

对细胞内病原体和癌症的免疫力依赖于强大的 CD8(+) T 细胞效应反应的产生以及免疫记忆的建立。在初级免疫反应期间，CD8(+) T 细胞会经历不同的细胞外环境线索和细胞间相互作用，从而触发下游转录程序，最终引导 CD8(+) T 细胞承担效应细胞或记忆细胞的命运。在这里，我们讨论了我们目前对调节 CD8(+) T 淋巴细胞中效应子和记忆承诺的信号通路和转录网络的理解。