当前位置:
X-MOL 学术
›
Trends Neurosci.
›
论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Development of human embryonic stem cell therapies for age-related macular degeneration
Trends in Neurosciences ( IF 15.9 ) Pub Date : 2013-07-01 , DOI: 10.1016/j.tins.2013.03.006 Amanda-Jayne F Carr 1 , Matthew J K Smart , Conor M Ramsden , Michael B Powner , Lyndon da Cruz , Peter J Coffey
Trends in Neurosciences ( IF 15.9 ) Pub Date : 2013-07-01 , DOI: 10.1016/j.tins.2013.03.006 Amanda-Jayne F Carr 1 , Matthew J K Smart , Conor M Ramsden , Michael B Powner , Lyndon da Cruz , Peter J Coffey
Affiliation
Age-related macular degeneration (AMD) is the leading cause of vision loss in older adults and ultimately leads to the death of photoreceptor cells in the macular area of the neural retina. Currently, treatments are only available for patients with the wet form of AMD. In this review, we describe recent approaches to develop cell-based therapies for the treatment of AMD. Recent research has focused on replacing the retinal pigment epithelium (RPE), a monolayer of cells vital to photoreceptor cell health. We discuss the various methods used to differentiate and purify RPE from human embryonic stem cells (HESC), and describe the surgical approaches being used to transplant these cells in existing and forthcoming clinical trials.
中文翻译:
人类胚胎干细胞治疗年龄相关性黄斑变性的发展
年龄相关性黄斑变性 (AMD) 是老年人视力丧失的主要原因,并最终导致神经视网膜黄斑区的感光细胞死亡。目前,治疗仅适用于湿性 AMD 患者。在这篇综述中,我们描述了开发用于治疗 AMD 的基于细胞的疗法的最新方法。最近的研究集中在替换视网膜色素上皮 (RPE),这是一种对光感受器细胞健康至关重要的单层细胞。我们讨论了用于从人类胚胎干细胞 (HESC) 中分化和纯化 RPE 的各种方法,并描述了在现有和即将进行的临床试验中用于移植这些细胞的手术方法。
更新日期:2013-07-01
中文翻译:
人类胚胎干细胞治疗年龄相关性黄斑变性的发展
年龄相关性黄斑变性 (AMD) 是老年人视力丧失的主要原因,并最终导致神经视网膜黄斑区的感光细胞死亡。目前,治疗仅适用于湿性 AMD 患者。在这篇综述中,我们描述了开发用于治疗 AMD 的基于细胞的疗法的最新方法。最近的研究集中在替换视网膜色素上皮 (RPE),这是一种对光感受器细胞健康至关重要的单层细胞。我们讨论了用于从人类胚胎干细胞 (HESC) 中分化和纯化 RPE 的各种方法,并描述了在现有和即将进行的临床试验中用于移植这些细胞的手术方法。