Despite a potential preventive effect of physical activity on hepatobiliary cancer, little information is available on the relation between the two. We studied the association between frequency of vigorous physical activity and hepatobiliary cancer among 507,897 participants of the NIH-AARP Diet and Health Study, aged 50-71 years at baseline in 1995/1996. During 10 years of follow-up, 628 incident cases of liver cancer and 317 cases of extrahepatic biliary tract cancer were registered. Physical activity levels were assigned according to the frequency of engagement in 20 min or more of vigorous physical activity per week: never/rarely (lowest level), less than once per week, 1-2 times per week, 3-4 times per week, 5 or more times per week (highest level). Using Cox regression, multivariate-adjusted relative risks (RR) comparing the highest with the lowest level of physical activity revealed a statistically significant decreased risk for liver cancer (RR = 0.64, 95% confidence interval (CI) = 0.49-0.84, p-trend <0.001), particularly hepatocellular carcinoma (RR = 0.56, 95% CI = 0.41-0.78, p-trend <0.001), independent of body mass index. By comparison, multivariate analyses indicated that physical activity was not statistically significantly associated with extrahepatic bile duct cancer (RR = 0.86, 95% CI = 0.45-1.65), ampulla of Vater cancer (RR = 0.66, 95% CI = 0.29-1.48), or gallbladder cancer (RR = 0.63, 95% CI = 0.33-1.21). These results suggest a potential preventive effect of physical activity on liver cancer but not extrahepatic biliary tract cancer, independent of body mass index.

中文翻译：

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NIH-AARP 饮食与健康研究中剧烈体力活动频率与肝胆癌之间的关联。

尽管体育锻炼对肝胆癌有潜在的预防作用，但关于两者之间关系的信息很少。我们在 1995/1996 年基线时年龄 50-71 岁的 NIH-AARP 饮食与健康研究的 507,897 名参与者中研究了剧烈体力活动的频率与肝胆癌之间的关联。在 10 年的随访中，登记了 628 例肝癌和 317 例肝外胆道癌。根据每周进行 20 分钟或以上剧烈体育活动的频率分配体育活动水平：从不/很少（最低水平）、每周少于一次、每周 1-2 次、每周 3-4 次, 每周 5 次或更多次（最高级别）。使用 Cox 回归，多变量调整的相对风险 (RR) 比较最高和最低水平的体力活动显示肝癌风险在统计学上显着降低（RR = 0.64，95% 置信区间 (CI) = 0.49-0.84，p 趋势 <0.001） ，尤其是肝细胞癌（RR = 0.56，95% CI = 0.41-0.78，p 趋势 <0.001），与体重指数无关。相比之下，多变量分析表明，体力活动与肝外胆管癌（RR = 0.86，95% CI = 0.45-1.65）、壶腹癌（RR = 0.66，95% CI = 0.29-1.48）无统计学意义或胆囊癌（RR = 0.63，95% CI = 0.33-1.21）。这些结果表明，体力活动对肝癌有潜在的预防作用，但对肝外胆道癌没有预防作用，与体重指数无关。