Daily rhythms are evident across our physiology, ranging from overt behavioural patterns like sleep to intricate molecular rhythms in epigenetic coding. Driving these rhythms at an anatomical and cellular level are circadian clock networks comprising core clock genes and an ever-expanding list of clock-controlled genes. Research over the past decade has revealed an intimate relationship between the clockwork and metabolic processes. In line with this, feeding behaviour in many species exhibits a strong circadian rhythm and, when restricted, food becomes the most potent entraining stimulus for clocks of the body. Critically, there are several indications that disturbance of our daily rhythms contributes to the development of obesity and diabetes. Given our 24-h society, it is important that we understand how the circadian clock influences what and when we eat.

中文翻译：

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摄食行为中的下丘脑时钟和节律

每天的节律在我们的生理学中是显而易见的，从睡眠等明显的行为模式到表观遗传编码中复杂的分子节律。在解剖学和细胞水平上驱动这些节律的是生物钟网络，包括核心时钟基因和不断扩大的时钟控制基因列表。过去十年的研究揭示了发条和代谢过程之间的密切关系。与此一致的是，许多物种的进食行为表现出强烈的昼夜节律，当受到限制时，食物成为对身体时钟最有效的刺激。至关重要的是，有几个迹象表明，我们日常节奏的紊乱会导致肥胖和糖尿病的发展。鉴于我们的 24 小时社会，