Type 1 diabetes is increasing dramatically in incidence in the developed world. While there may be several reasons for this, improved sanitation and public health measures have altered our interactions with certain infectious agents such as helminths. There is increasing interest in the use of helminths or their products to alleviate inflammatory or allergic conditions. Using rodent models of diabetes, it has been possible to explore the therapeutic potential of both live infections as well as helminth-derived products on the development of autoimmunity. This review provides an overview of the findings from animal models and additionally explores the potential for translation to the clinic.

中文翻译：

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蠕虫介导的 1 型糖尿病 (T1D) 调节。

在发达国家，1 型糖尿病的发病率正在急剧上升。虽然这可能有几个原因，但改善的卫生和公共卫生措施已经改变了我们与某些传染性病原体（如蠕虫）的互动。人们越来越关注使用蠕虫或其产品来缓解炎症或过敏状况。使用糖尿病啮齿动物模型，可以探索活体感染和蠕虫衍生产品对自身免疫发展的治疗潜力。本综述概述了动物模型的研究结果，并进一步探索了转化为临床的潜力。