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Reprogramming and development in nuclear transfer embryos and in interspecific systems.
Current Opinion in Genetics & Development ( IF 4 ) Pub Date : 2012-10-16 , DOI: 10.1016/j.gde.2012.09.002
Patrick Narbonne 1 , Kei Miyamoto , J B Gurdon
Affiliation  

Nuclear transfer (NT) remains the most effective method to reprogram somatic cells to totipotency. Somatic cell nuclear transfer (SCNT) efficiency however remains low, but recurrent problems occurring in partially reprogrammed cloned embryos have recently been identified and some remedied. In particular, the trophectoderm has been identified as a lineage whose reprogramming success has a large influence on SCNT embryo development. Several interspecific hybrid and cybrid reprogramming systems have been developed as they offer various technical advantages and potential applications, and together with SCNT, they have led to the identification of a series of reprogramming events and responsible reprogramming factors. Interspecific incompatibilities hinder full exploitation of cross-species reprogramming systems, yet recent findings suggest that these may not constitute insurmountable obstacles.

中文翻译:

核移植胚胎和种间系统中的重编程和发育。

核移植 (NT) 仍然是将体细胞重编程为全能性的最有效方法。然而,体细胞核移植 (SCNT) 效率仍然很低,但最近已发现部分重编程的克隆胚胎中经常出现的问题,并对其进行了一些补救。特别是,滋养外胚层已被确定为重编程成功对 SCNT 胚胎发育有很大影响的谱系。已经开发了几种种间杂种和杂种重编程系统,因为它们提供了各种技术优势和潜在应用,并且与 SCNT 一起,它们导致了一系列重编程事件和负责任的重编程因素的识别。种间不相容性阻碍了跨物种重编程系统的充分利用,
更新日期:2012-10-11
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